Regulation of the G2/M Transition in Rodent Oocytes [PDF]
, 2010 Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
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Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system [PDF]
, 1981 The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism.
Davis, Ronald L., Kiger, John A., Jr.
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Age related histopathological and immunohistochemical changes in horse brains [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017 The aim of this study was to investigate age dependent pathological changes in horse brains. In the study, 10 mature horses aged between 10-16 years, 13 old horses aged between 17-21 years old and 7 young horses between 4-7 years old were examined ...
ÖZSOY ŞY, HAZIROĞLU R
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Effect of knocking down the insulin receptor on mouse rod responses. [PDF]
, 2015 Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L +3 more
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Frontiers in Pharmacology, 2020 With the identification of novel cAMP binding effector molecules in Trypanosoma, the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough.
Amrita Saha +5 more
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Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes [PDF]
Hormone and Metabolic Research, 2012 The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the regulation of intracellular concentrations of cyclic nucleotides and cyclic nucleotide-dependent signaling pathways. Two PDE3 subfamilies, PDE3A and PDE3B, have been described.
F, Ahmad, E, Degerman, V C, Manganiello
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Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis
Frontiers in Pharmacology, 2023 Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3–5 years.
Xudan Yang +3 more
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Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP [PDF]
, 1983 Voltage-clamped atrial trabeculae from bullfrog hearts were exposed to membrane-permeant photolyzable o-nitrobenzyl esters of cAMP and cGMP. UV flashes produced intracellular concentration jumps of cAMP or cGMP. With the cAMP derivative, flashes resulted
Engels, Joachim +3 more
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Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]
, 2013 The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton +8 more
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Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases [PDF]
Biochemical and Biophysical Research Communications, 2002 We have compared selected biophysical properties of three phosphodiesterases, from Arabidopsis thaliana, Saccharomyces cerevisiae, and Escherichia coli. All of them belong to a recently identified family of cyclic nucleotide phosphodiesterases. Experiments elucidating folding stability, protein fluorescence, oligomerization behavior, and the effects of
Hofmann, A +6 more
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