Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system [PDF]
, 1981 The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism.
Davis, Ronald L., Kiger, John A., Jr.
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Cancer Communications, EarlyView.Abstract Background The ASTRUM‐005 study previously demonstrated a significant overall survival (OS) benefit with serplulimab (a programmed death 1 inhibitor) plus chemotherapy versus chemotherapy alone in previously untreated extensive‐stage small‐cell lung cancer (ES‐SCLC).
Ying Cheng +32 more
wiley +1 more source
Brain Sciences, 2021 The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely.
David C. Platt +4 more
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Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]
, 1994 This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
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Cancer Communications, EarlyView.Abstract Background Gastric cancer peritoneal metastasis is clinically challenging, given the limited treatment options and poor prognosis. The molecular mechanisms that precede gastric cancer peritoneal metastasis, known as the pre‐metastatic niche (PMN), and its relationship with N6‐methyladenosine (m6A) modification remain unclear.
Song Li +23 more
wiley +1 more source
Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus
Frontiers in Molecular Neuroscience, 2019 Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in ...
Susan McQuown +7 more
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Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase. [PDF]
PLoS ONE, 2015 The second messenger nucleotide cyclic diadenylate monophosphate (c-di-AMP) has been identified in several species of Gram positive bacteria and Chlamydia trachomatis. This molecule has been associated with bacterial cell division, cell wall biosynthesis
Christina R Savage +7 more
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Second messenger systems underlying amine and peptide actions on cardiac muscle in the horseshoe crab, Limulus polyphemus [PDF]
, 1989 The biochemical mechanisms by which octopamine, catecholamines and the peptide proctolin exert their actions on Limulus cardiac muscle were investigated.
Groome, J. R., Watson, Winsor H., III
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Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]
, 2013 The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton +8 more
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A Fluorescence Polarization Assay for Cyclic Nucleotide Phosphodiesterases [PDF]
Journal of Biomolecular Screening, 2002 Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 3'-ester bond of cyclic AMP (cAMP) and cyclic GMP (cGMP), important second messengers in the transduction of a variety of extracellular signals. There is growing interest in the study of PDEs as drug targets for novel therapeutics.
Wei Huang +2 more
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