Results 81 to 90 of about 42,131 (286)

Atrial cardiomyopathy: From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
The diagnosis of atrial cardiomyopathy (AtCM) requires electrical atrial dysfunction, with evidence of either mechanical atrial dysfunction, atrial enlargement, or excessive atrial fibrosis. The diagnostic cut‐points presented are for standard electrocardiogram and echocardiogram studies (see Figure 1 for further detail).
Jerremy Weerts, Otilia Țica, Julia Aranyo, Christian Basile, Angelina Borizanova‐Petkova, Josip Andjelo Borovac, Massimiliano Camilli, Martin Eichenlaub, Emiliano Fiori, Tim Van Loon, Coenraad Withaar, Diana Zakarkaitė, Matthias D. Zink, Marianna Adamo, Alberto Aimo, Elena Arbelo, Felipe Bisbal Van Bylen, Dimitrios T. Farmakis, Dobromir Dobrev, Jelena Čelutkienė, Michael Böhm, Andrew Coats, Marco Metra, Giuseppe Rosano, Frank Ruschitzka, Antoni Bayes‐Genis, Dipak Kotecha   +26 more
wiley   +1 more source

Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo, CECI GALANOS, Roberta, Crescioli, Clara, Di Luigi, Luigi, Duranti, Guglielmo, Sabatini, Stefania, Sansone, Andrea, Sansone, Massimiliano, Sgrò, Paolo   +8 more
core   +1 more source

Cyclic nucleotide phosphodiesterases in Drosophila melanogaster [PDF]

Biochemical Journal, 2005
Cyclic nucleotide PDEs (phosphodiesterases) are important enzymes that regulate intracellular levels of cAMP and cGMP. In the present study, we identify and characterize novel PDEs in the genetic model, Drosophila melanogaster. The Drosophila genome encodes five novel PDE genes in addition to dunce.
Julian A. T. Dow, Miles D. Houslay, Jonathan P. Day, Shireen A. Davies   +3 more
openaire   +3 more sources

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, EarlyView.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Inhibitors of cyclic nucleotide phosphodiesterases produced by streptomyces. I. Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases.

Agricultural and Biological Chemistry, 1977
About 1,200 microbial cultured filtrates have been screened for inhibition of cyclic nucleotide phosphodiesterases (EC 3.1.4.c] prepared from rabbit brains. One of the active agents was isolated and identified as reticulol (6,8-dihydroxy-7-methoxy-3-methylisocoumarin).
Yoshio Furutani, Masa Hamada, Masao Shimada, Tonaio Takeuchi, Hamao Umezawa   +4 more
openaire   +3 more sources

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode Caenorhabditis elegans

Cells
Cyclic nucleotide signaling pathways play essential roles in the physiology of the nematode Caenorhabditis elegans, influencing processes such as reproduction, environmental sensing, and cellular homeostasis. The intracellular levels of cAMP and cGMP are
Kranti K. Galande, Rick H. Cote
doaj   +1 more source

Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells

Scientific Reports, 2017
Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system.
Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana   +3 more
doaj   +1 more source

The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]

, 2018
Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
core   +2 more sources

Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes [PDF]

Hormone and Metabolic Research, 2012
The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the regulation of intracellular concentrations of cyclic nucleotides and cyclic nucleotide-dependent signaling pathways. Two PDE3 subfamilies, PDE3A and PDE3B, have been described.
Vincent C. Manganiello, Faiyaz Ahmad, Eva Degerman   +2 more
openaire   +3 more sources