Damage Signaling by Extracellular Nucleotides: A Role for Cyclic Nucleotides in Elevating Cytosolic Free Calcium? [PDF]
Frontiers in Plant Science, 2021 Extracellular ATP (eATP) is now held to be a constitutive damage-associated molecular pattern (DAMP) that is released by wounding, herbivory or pathogen attack.
Jian Sun +5 more
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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases [PDF]
Frontiers in Endocrinology, 2023 The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan +4 more
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Cyclic nucleotide signalling in malaria parasites [PDF]
Open Biology, 2017 The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
David A. Baker +6 more
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Cross Talk Between Cyclic Nucleotides and Calcium Signaling Pathways in Plants–Achievements and Prospects [PDF]
Frontiers in Plant Science, 2021 A variety of plant cellular activities are regulated through mechanisms controlling the level of signal molecules, such as cyclic nucleotides (cNMPs, e.g., cyclic adenosine 3′:5′-monophosphate, cAMP, and cyclic guanosine 3′:5′- monophosphate, cGMP) and ...
Brygida Świeżawska-Boniecka +4 more
doaj +2 more sources
Downstream Targets of Cyclic Nucleotides in Plants [PDF]
Frontiers in Plant Science, 2018 Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska +3 more
doaj +2 more sources
Establishing a sensitive fluorescence-based quantification method for cyclic nucleotides [PDF]
BMC Biotechnology, 2020 Background Approximately 40% of prescribed drugs exert their activity via GTP-binding protein-coupled receptors (GPCRs). Once activated, these receptors cause transient changes in the concentration of second messengers, e.g., cyclic adenosine 3′,5 ...
Nadine Gruteser +9 more
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“Cyclic nucleotides in plants: from obscure messengers to central regulators“ [PDF]
Frontiers in Plant ScienceThis review examines the historical trajectory of cyclic nucleotides (cNMPs) research in plants, a field that has encountered prolonged challenges and skepticism, contrasting sharply with its rapid validation in animal systems.
Brygida Świeżawska-Boniecka +1 more
doaj +2 more sources
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel. [PDF]
Nat Struct Mol Biol, 2023 Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cyclic nucleotide-modulated and cyclic nucleotide-gated channels, especially at the level of the cyclic nucleotide ...
Pan Y +6 more
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Fluorescence Titrations to Determine the Binding Affinity of Cyclic Nucleotides to SthK Ion Channels [PDF]
Bio-Protocol, 2018 The cyclic-nucleotide modulated ion channel family includes cyclic nucleotide-gated (CNG) and hyperpolarization-activated and cyclic nucleotide-modulated (HCN) channels, which play essential roles in visual and olfactory signaling and the heart ...
Philipp Schmidpeter, Crina Nimigean
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The Role of Cyclic Nucleotides in Pituitary Lactotroph Functions [PDF]
Frontiers in Endocrinology, 2013 Lactotrophs are one of the five secretory anterior pituitary cell types specialized to synthesize and release prolactin. In vitro, these cells fire action potentials spontaneously and the accompanied Ca2+ transients are of sufficient amplitude to keep ...
Marek eKucka +3 more
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