Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Experimental approaches to understanding the role of protein phosphorylation in the regulation of neuronal function [PDF]
, 1983 Studies by Earl Sutherland and his colleagues on hormonal regulation of the breakdown of glycogen in liver resulted in the discovery that the first step in the action of many hormones is to increase the synthesis of cAMP by activating adenylate cyclase ...
Kennedy, Mary B.
core
Tunable and Recyclable Piezoelectric Biomaterials via Ion‐Directed Guanine‐Quadruplex Assembly
Advanced Functional Materials, EarlyView.Guanine‐quadruplex (GQ) assemblies, formed via ion‐mediated self‐assembly of amphiphilic guanine derivatives, are introduced as tunable and recyclable piezoelectric biomaterials. Distinct alkali ions induce unique dipole configurations and piezoelectric outputs, with K⁺ yielding the highest performance.
Seungho Lee +9 more
wiley +1 more source
Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders. [PDF]
Mol Biol Rep, 2023 Gutiérrez-Rodelo C +5 more
europepmc +1 more source
ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]
, 1989 The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors [PDF]
, 1987 M. L. REEVES, B. K. Leigh, P. England
openalex +1 more source
Advanced Functional Materials, EarlyView.A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao +11 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]
, 1982 We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
core
β Subunits of the Olfactory Cyclic Nucleotide-Gated Channel Form a Nitric Oxide Activated Ca2+ Channel [PDF]
, 1997 Marie-Christine Broillet +1 more
openalex +1 more source