SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]
, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E +10 more
core
Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering
Advanced Functional Materials, EarlyView.This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le +14 more
wiley +1 more source
Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels
Advanced Functional Materials, EarlyView.Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard +8 more
wiley +1 more source
Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism. [PDF]
Int J Mol Sci, 2021 Huang CJ +10 more
europepmc +1 more source
Bio‐Inspired Molecular Events in Poly(Ionic Liquids)
Advanced Functional Materials, EarlyView.Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley +1 more source
Role of phosphodiesterase 5 in synaptic plasticity and memory
Neuropsychiatric Disease and Treatment, 2008 Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain ...
Daniela Puzzo +3 more
doaj
Advanced Healthcare Materials, EarlyView.We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak +6 more
wiley +1 more source
Cyclic nucleotides in mechano-transduction and encoding processes.
, 1989 Masahiro Sokabe +2 more
openalex +2 more sources
Bacterial origins of cyclic nucleotide-activated antiviral immune signaling [PDF]
, 2022 Dinshaw J. Patel, You Yu, Ning Jia
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao +20 more
wiley +1 more source