Results 171 to 180 of about 121,582 (318)

The Panoptes system uses decoy cyclic nucleotides to defend against phage. [PDF]

Nature
Sullivan AE, Nabhani A, Izrailevsky DS, Schinkel K, Hoffman CRK, Robbins LK, Nagy TA, Duncan ML, Ledvina HE, Erbse AH, Kibby EM, Tak U, Dinh DM, Ednacot EMQ, Nguyen CM, Burroughs AM, Aravind L, Whiteley AT, Morehouse BR.   +18 more
europepmc   +1 more source

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

, 1998
Scott H. Soderling, Sharon J. Bayuga, Joseph A. Beavo   +2 more
openalex   +2 more sources

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles. [PDF]

Proc Natl Acad Sci U S A
Nakashima IF, Zhong H, Nikolaev VO, Owen CM, Yee SP, Jaffe LA, Egbert JR.   +6 more
europepmc   +1 more source

Similar Binding Modes of cGMP Analogues Limit Selectivity in Modulating Retinal CNG Channels via the Cyclic Nucleotide-Binding Domain [PDF]

Palina Pliushcheuskaya, Sandeep Kesh, E. Kaufmann, Sophie Wucherpfennig, Frank Schwede, Georg Künze, Vasilica Nache   +6 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

High-Yield Prebiotic Polymerization of 2',3'-Cyclic Nucleotides under Wet-Dry Cycling. [PDF]

ACS Cent Sci
Caimi F, Langlais J, Fontana F, Wunnava S, Bellini T, Braun D, Fraccia TP.   +6 more
europepmc   +1 more source

Changes in cyclic nucleotides (cyclic AMP and cyclic GMP) of regenerating liver following partial hepatectomy in D-galactosamine-injured liver.

, 1984
Masaru Miyazaki, Shigeru Fujimoto, Setsuko Fujita, F Endoh, Takanori SHIMURA, H Sugasawa, Osamu Takahashi, Masatoshi Kurihara, Shigemi KAWADA, H Koshikawa, Ikuo Udagawa, Katsuji Okui   +11 more
openalex   +2 more sources

Cyclic nucleotides and GTP analogues stimulate light‐induced phosphorylation of octopus rhodopsin [PDF]

, 1989
Motoyuki Tsuda, Tomoko Tsuda, Hajime Hirata   +2 more
openalex   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source