Results 181 to 190 of about 121,582 (318)

Innovative Cyclic Nucleotides - Nucleoside 2',3'-Seven-Membered Cyclic Diphosphonate Derivatives. Theoretical Feasibility, Synthesis, and Properties. [PDF]

Chemistry
Liberman S, Bobot L, Ben Daniel HT, Major DT, Fischer B.   +4 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Dioscin from smilax china rhizomes inhibits platelet activation and thrombus formation via up-regulating cyclic nucleotides. [PDF]

Sci Rep
Lee GH, Lee JP, Heo NY, Lee CD, Kim G, Wahab AA, Rhee MH, Lee S, Lee DH.   +8 more
europepmc   +1 more source

Demonstration of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies.

, 1984
Rajendra K. Sharma, A M Adachi, Kei Adachi, J H Wang   +3 more
openalex   +1 more source

Cyclic nucleotide selectivity of protein kinase G isozymes [PDF]

, 2020
Choel Kim, Rajesh Sharma
openalex   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy. [PDF]

Pharmacol Ther, 2019
Knowles RB, Warner TD.
europepmc   +1 more source

Effects of cyclic nucleotides on the function of prestin

, 2005
Levente Deák, Jing Zheng, Alex Orem, Guo‐Guang Du, Salvador Aguiñaga, Keiji Matsuda, Peter Dallos   +6 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. [PDF]

Nat Struct Mol Biol
Rechkoblit O, Sciaky D, Kreitler DF, Buku A, Kottur J, Aggarwal AK.   +5 more
europepmc   +1 more source