Advanced Science, EarlyView.Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo +12 more
wiley +1 more source
Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides. [PDF]
J Biol Chem, 2016 DeBerg HA +4 more
europepmc +1 more source
The Role of Cyclic Nucleotides in Axon Guidance
, 2007 Michael Piper +2 more
openalex +2 more sources
Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
New approaches regarding the in vitro maturation of oocytes: manipulating cyclic nucleotides and their partners in crime. [PDF]
JBRA Assist Reprod, 2017 Botigelli RC +3 more
europepmc +1 more source
Antigen-stimulated changes in cyclic nucleotide levels in the mouse.
, 1975 Ikuo Yamamoto, David R. Webb
openalex +2 more sources
Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012 [PDF]
, 2016 Susann Schröder +4 more
openalex +1 more source
Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes
Advanced Science, EarlyView.Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji +12 more
wiley +1 more source
Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation. [PDF]
Sci Rep, 2018 Otte M +6 more
europepmc +1 more source
Determination and quantification of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by HILIC SPE in combination with LC-MS/MS [PDF]
, 2012 Lynen, Frederic +3 more
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