A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic fibrosis transmembrane conductance regulator protein [PDF]
, 1999 Margaret A. McPherson +4 more
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Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Advanced Science, EarlyView.Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou +14 more
wiley +1 more source
Advanced Science, EarlyView.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source
Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides. [PDF]
Biophys J, 2015 Thon S, Schulz E, Kusch J, Benndorf K.
europepmc +1 more source
State of Cytidine 3\u27, 5\u27 Cyclic Monophosphate (Cyclic CMP) Research [PDF]
, 1981 Murphy, Bruce E., Stone, Joseph E.
core +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Cardiac Cyclic Nucleotide Phosphodiesterases: Function, Regulation, and Therapeutic Prospects
, 2012 Walter E. Knight, Yan Chen
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Structural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels [PDF]
, 2013 Sven Schünke, Matthias Stoldt
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