Results 191 to 200 of about 162,229 (257)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery. [PDF]

Nat Commun
Petrov D, Plais L, Schira K, Cai J, Keller M, Lessing A, Bassi G, Cazzamalli S, Neri D, Gloger A, Scheuermann J.   +10 more
europepmc   +1 more source

Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba <i>Balamuthia mandrillaris</i>. [PDF]

J Nat Prod
Lu C, Nelson S, Coy G, Neumann C, Parkinson EI, Rice CA.   +5 more
europepmc   +1 more source

Author Correction: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α. [PDF]

Sci Rep
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J.   +17 more
europepmc   +1 more source

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation. [PDF]

Nat Commun
Bertran MT, Walmsley R, Cummings T, Aramburu IV, Benton DJ, Mora Molina R, Assalaarachchi J, Chasampalioti M, Swanton T, Joshi D, Federico S, Okkenhaug H, Yu L, Oxley D, Walker S, Papayannopoulos V, Suga H, Christophorou MA, Walport LJ.   +18 more
europepmc   +1 more source

Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers. [PDF]

RSC Chem Biol
Katzy RE, van Neer RHP, Ferraz MJ, Nicolai K, Passioura T, Suga H, Jongkees SAK, Artola M.   +7 more
europepmc   +1 more source

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Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

ChemBioChem, 2012
Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower ...
Lei Liu, Ji-Shen Zheng
exaly   +3 more sources

Orally Absorbed Cyclic Peptides [PDF]

Chemical Reviews, 2017
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active transport mechanisms facilitate cell uptake of only very small peptides. Systematic evaluations of peptides
Daniel S. Nielsen, Nicholas E. Shepherd, Weijun Xu, Andrew J. Lucke, Martin J. Stoermer, David P. Fairlie   +5 more
openaire   +4 more sources

Rotaxanes of Cyclic Peptides

Journal of the American Chemical Society, 2006
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Vincent, Aucagne, David A, Leigh, Julia S, Lock, Andrew R, Thomson   +3 more
openaire   +2 more sources

Cyclic Peptides

International Journal of Peptide and Protein Research, 1986
In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA, KOICHI IKESUE, SANNAMU LEE, HARUHIKO AOYAGI, TETSUO KATO, TAMIO UENO, NOBUO IZUMIYA   +6 more
  +4 more sources