Results 181 to 190 of about 2,011,052 (344)

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Cyclic beta-hairpin-based peptide binders

, 2015
The present invention provides a cyclic β-hairpin based peptide binder having a novel construct. The cyclic β-hairpin based peptide binder of the present invention can be used as a medicine, can be used for detection of in vivo materials, in vivo ...
김대진, 전상용, 전형수
core  

PolyGraph – Flexible, Biocompatible & Electrically Optimized Graphene‐Polymer Composites for Next‐Generation Neural Interfaces

Advanced Healthcare Materials, EarlyView.
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti, Eoin Caffrey, Jose M. Munuera, Tian Carey, Adrian Dervan, Alejandro López Valdés, Omar Mamad, Maeve A. Caldwell, Fergal J. O'Brien, Jonathan N. Coleman   +12 more
wiley   +1 more source

SICLOPPS cyclic peptide libraries in drug discovery.

Current Opinion in Chemical Biology, 2017
A. Tavassoli
semanticscholar   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Structure-based design and optimization of cyclic peptide ligands targeting delta-like ligand 3. [PDF]

RSC Adv
Gao X, Zha X, Liu W, Xie J, Gao J, Luo Z.   +5 more
europepmc   +1 more source

MSF-CPMP: a novel multi-source feature fusion model for prediction of cyclic peptide membrane permeability [PDF]

Brief Bioinform
Zhang Y, Chen Z, Wan Z, Jiang Q, Lu X, Yan B, Qin J, Liu Y, Wang J.   +8 more
europepmc   +2 more sources

pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets.

Nanoscale Horizons, 2018
Alejandro Méndez‐Ardoy, J. Granja, J. Montenegro   +2 more
semanticscholar   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Parameterizing non-canonical amino acids for cyclic peptide simulations. [PDF]

Methods Enzymol
Wijesiri NK, Brown BP.
europepmc   +1 more source