Results 221 to 230 of about 864,219 (292)

Impact of stereochemical replacement on activity and selectivity of membrane-active antibacterial and antifungal cyclic peptides. [PDF]

NPJ Antimicrob Resist
Lohan S, Konshina AG, Mohammed EHM, Helmy NM, Jha SK, Tiwari RK, Maslennikov I, Efremov RG, Parang K.   +8 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Design and Production of Geranylated Cyclic Peptides by the RiPP Enzymes SyncM and PirF. [PDF]

Biomacromolecules
Xu Y, Ruijne F, Diez MG, Stada JJ, Kuipers OP.   +4 more
europepmc   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders. [PDF]

ACS Med Chem Lett
Hu QL, Liang SH.
europepmc   +1 more source

Genetically Encoded <i>Levivirus</i> Coat Protein-Based Yeast Display Libraries of Cyclic Peptides. [PDF]

ACS Synth Biol
Simak T, Stracke F, Smrzka O, Wozniak-Knopp G.   +3 more
europepmc   +1 more source

Natural and Designed Cyclic Peptides as Potential Antiviral Drugs to Combat Future Coronavirus Outbreaks. [PDF]

Molecules
Uwamahoro H, Collier WE, Nashar TO, Jaynes JM, Mortley DG, Davis CG, Kanyairita GG, Abdelazim EF, Igiramaboko JFR, Habineza C, Tumushimiyimana D, Rutayisire UN, Davis YA, Renard KL.   +13 more
europepmc   +1 more source

Identification and Validation of Cyclic Peptides with Mucin-Selective, Location-Specific Binding in the Gastrointestinal Tract. [PDF]

ACS Nano
Subramanian DA, Chin A, Shi Y, Liu GW, Langer R, Traverso G.   +5 more
europepmc   +1 more source