Results 231 to 240 of about 864,219 (292)

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors. [PDF]

iScience
Gray JP, Bildik G, Kim HN, Sutton MN, Wang J, Osuji AO, Batistatou N, Yang H, Mao W, Tan Z, Gasmi-Seabrook GMC, Liu J, Hancock JF, Marshall CB, Kritzer JA, Ikura M, Bast RC, Millward SW, Lu Z.   +18 more
europepmc   +1 more source

Peptide-Aware Chemical Language Model Successfully Predicts Membrane Diffusion of Cyclic Peptides. [PDF]

J Chem Inf Model
Feller AL, Wilke CO.
europepmc   +1 more source

Ligation Technologies for the Synthesis of Cyclic Peptides

Chemical Reviews, 2019
Cyclic peptides have been attracting a lot of attention in recent decades, especially in the area of drug discovery, as more and more naturally occurring cyclic peptides with diverse biological activities have been discovered.
Xuechen Li, Yue Zhang, Hoi Yee Chow
exaly   +2 more sources

Cyclic Peptides for Drug Development [PDF]

Angewandte Chemie - International Edition
Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives.
Christian Heinis, Alexander Lund Nielsen, Xinjian Ji   +2 more
exaly   +3 more sources

Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides [PDF]

Chemical Reviews, 2021
This Review focuses on the establishment and development of self-assemblies governed by the supramolecular interactions between cyclic peptides. The Review first describes the type of cyclic peptides able to assemble into tubular structures to form ...
Sébastien Perrier, Qiao Song, Stephen Hall   +2 more
exaly   +2 more sources

Orally Absorbed Cyclic Peptides [PDF]

Chemical Reviews, 2017
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active transport mechanisms facilitate cell uptake of only very small peptides. Systematic evaluations of peptides
Nicholas Shepherd, Weijun Xu, Andrew J Lucke   +2 more
exaly   +5 more sources

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Rotaxanes of Cyclic Peptides

Journal of the American Chemical Society, 2006
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Aucagne, Vincent, Leigh, David, Lock, Julia, Thomson, Andrew   +3 more
openaire   +2 more sources

Cyclic Peptides

International Journal of Peptide and Protein Research, 1986
In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA, KOICHI IKESUE, SANNAMU LEE, HARUHIKO AOYAGI, TETSUO KATO, TAMIO UENO, NOBUO IZUMIYA   +6 more
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Homodetic Cyclic Peptides

ChemInform, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Cyclic peptides

International Journal of Peptide and Protein Research, 1985
cyclo(‐l‐Pro‐l‐Val‐l‐Pro‐l‐Val‐) (1L) and cyclo(‐l‐Pro‐d‐Val‐l‐Pro‐d‐Val‐) (1D) were synthesized by the conventional method for peptide synthesis. Conformations of 1L and 1D in solution were studied. Compound 1L has a cis‐trans‐cis‐trans backbone conformation with C2 symmetry in CDCl3.
TOMALIA DONALD A, WILSON LARRY R
openaire   +4 more sources