Results 81 to 90 of about 211,010 (331)

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]

, 2018
Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent, Hollenbach, Jill, Misra, Maneesh   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Computational prediction of plasma protein binding of cyclic peptides from small molecule experimental data using sparse modeling techniques

BMC Bioinformatics, 2018
Background Cyclic peptide-based drug discovery is attracting increasing interest owing to its potential to avoid target protein depletion. In drug discovery, it is important to maintain the biostability of a drug within the proper range.
Takashi Tajimi, Naoki Wakui, Keisuke Yanagisawa, Yasushi Yoshikawa, Masahito Ohue, Yutaka Akiyama   +5 more
doaj   +1 more source

Binding Interactions of Peptide Aptamers

Molecules, 2020
Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located
Roger R. C. New, Tam T. T. Bui, Michal Bogus   +2 more
doaj   +1 more source

Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer [PDF]

, 1985
Resact, a peptide of known sequence isolated from the jelly layer of Arbacia punctulata eggs, is a potent chemoattractant for A. punctulata spermatozoa. The chemotactic response is concentration dependent, is abolished by pretreatment of the spermatozoa ...
Brokaw, Charles J., Garbers, David L., Vacquier, Victor D., Ward, Gary E.   +3 more
core   +3 more sources

CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]

, 2020
Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor, Lajevardi, Aryan, Matei, Andreea, Paluzzi, Jean-Paul, Paputsis, Christine, Sajadi, Farwa, Uyuklu, Ali, Wahedi, Azizia   +7 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

MultiCycPermea: accurate and interpretable prediction of cyclic peptide permeability using a multimodal image-sequence model

BMC Biology
Background Cyclic peptides, known for their high binding affinity and low toxicity, show potential as innovative drugs for targeting “undruggable” proteins. However, their therapeutic efficacy is often hindered by poor membrane permeability.
Zixu Wang, Yangyang Chen, Yifan Shang, Xiulong Yang, Wenqiong Pan, Xiucai Ye, Tetsuya Sakurai, Xiangxiang Zeng   +7 more
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

Study of (cyclic peptide)-polymer conjugate assemblies by small-angle neutron scattering [PDF]

, 2016
We present a fundamental study into the self-assembly of (cyclic peptide)–polymer conjugates as a versatile supramolecular motif to engineer nanotubes with defined structure and dimensions, as characterised in solution using small-angle neutron ...
Aida, Blunden, Brea, Börner, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Clark, Clark, Couet, Couet, Couet, Danial, De Greef, de la Rica, Fernandez-Lopez, Fields, Gao, García-Fandiño, Ghadiri, Ghadiri, Ghadiri, Goddard-Borger, Goddard-Borger, Gokhale, Granja, Hartgerink, Hourani, Huang, Ketchem, Ketchem, Khazanovich, Kim, Kline, Klok, Klug, Konkolewicz, Li, Loschonsky, Martin, Merrifield, Mizrahi, Moss, Namba, Ogi, Ogi, Poon, Porod, Porod, Ramesh, Raw, Scanlon, Sears, Sheiko, Shimizu, Song, Suga, Taira, Tasis, ten Cate, Vandermeulen, Wang, Xu, Zhang, Zhao   +68 more
core   +1 more source