Results 81 to 90 of about 8,950,425 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Continuous Thermogravimetry under Cyclic Conditions [PDF]
, 2004 Thermogravimetry during cyclic oxidation of metallic alloys is described. A methodology is given in order to determine the Net Mass Gain, the GrossMass Gain, the total mass of spalled oxide, the rate of metal consumption and the average oxide scale ...
Poquillon, Dominique, Monceau, Daniel
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Test on Cyclic Bending of Riser Flexible Joint
Shiyou jixie, 2018 Based on the working condition and functional characteristics of the flexible joint of the riser, the cyclic bending performance of the flexible joint was tested.
Huang Ping +6 more
doaj
Applied Ocean ResearchThis paper investigates the behavior of a monopile-gravity-shallow bucket (MGB) hybrid foundation for offshore wind turbines (OWTs) under cyclic loading conditions. The study aims to understand the long-term performance of the hybrid foundation, focusing
Xinyao Li +5 more
doaj +1 more source
Properties on Shear Fatigue Performance of Reinforced Asphalt Overlays [PDF]
E3S Web of ConferencesRecent advances in pavement design have emphasized the role of cyclic shear stiffness in predicting asphalt fatigue performance. However, the behavior of geosynthetic-reinforced asphalt overlays under shear fatigue loading remains insufficiently ...
Pena da Silva e Silva Matheus +1 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Reinforced sol–gel thermal barrier coatings and their cyclic oxidation life [PDF]
, 2013 Cyclic oxidation life enhancement of sol–gel thermal barrier coatings is obtained via the reinforcement of the controlled micro-crack network that forms during the initial sintering of the deposit.
Ansart, Florence +5 more
core +1 more source