Results 91 to 100 of about 220,758 (314)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Behavior of FRP-Concrete Beam-Columns under Cyclic Loading

open access: yes, 2003
Use of concrete-filled fiber-reinforced polymers (FRP) tubes (CFFT) for columns and piles has been studied extensively over the last decade. The focus, however, has been exclusively on the monotonic behavior of CFFT.
Shao, Yutian
core  

Undrained monotonic and cyclic shear characteristics of marine silty clay under various consolidation stress levels

open access: yesApplied Ocean Research
The undrained monotonic and cyclic shear characteristics of marine silty clay are essential for evaluating the long-term performance and safety of coastal and marine structures.
Tang Yan   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading

open access: yes, 2012
The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Varum, H., Rossetto, T., Borg, R. C.
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Effects of principal stress rotation and drainage on the resilient stiffness of railway foundations

open access: yes, 2013
Railway foundations play an integral role in controlling the stability of the overlying track structure and the maintenance of the overall track geometry.
Mamou, A.
core  

Low cycle fatigue life improvement of AISI 304 by initial and intermittent wire brush hammering [PDF]

open access: yes, 2013
The effects of hammering by wire brush as a method of improving low cycle fatigue life of highly ductile austenitic stainless steel AISI 304 have been investigated through an experimental study combining imposed strain fatigue tests and assessment of ...
KHLIFI, Ammar   +4 more
core   +1 more source

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