Results 101 to 110 of about 330,923 (308)

Environmental Assessment Methods for Dissolution of Soil [PDF]

Nature Environment and Pollution Technology
Water plays a crucial role in the environment and in the process of liquefaction, which can occur during moderate to major earthquakes and cause significant structural damage.
Deepanjali Sahu􀀃, M. K. Tiwari􀀃 and Arunachal Sahu
doaj   +1 more source

Constitutive modeling of the anisotropic behavior of Mullins softened filled rubbers [PDF]

, 2003
Original constitutive modeling is proposed for filled rubber materials in order to capture the anisotropic softened behavior induced by general non-proportional pre-loading histo-ries.
Bouvier, P, Chaabane, B, Dkhil, B, Glazer, A M, Kreisel, J, Mezouar, M, Thomas, P.R., Welberry, Thomas   +7 more
core   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Energy-based ue - εvp coupled incremental model of saturated marine coral sand subjected to cyclic loading

Applied Ocean Research
Evaluating the stability of coral islands and reefs in dynamic marine environments, such as waves, tsunamis, storm surges, and earthquakes, is a critical scientific issue in the field of marine geotechnical engineering.
Yi Fang, Kai Ren, Qi Wu, Qifei Liu, Guoxing Chen   +4 more
doaj   +1 more source

Non-local energy based fatigue life calculation method under multiaxial variable amplitude loadings [PDF]

, 2013
Reliable design of industrial components against high cycle multiaxial fatigue requires a model capable of predicting both stress gradient and load type effects. Indeed, taking into account gradient effects is of prior importance for the applicability of
BÉNABÈS, Jérôme, COCHETEUX, Francis, PALIN-LUC, Thierry, SAINTIER, Nicolas   +3 more
core   +6 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental investigation on volumetric strain accumulation of saturated marine sands subjected to wave-induced complex cyclic loading

Frontiers in Earth Science
The dilatancy of marine sands highly depends on the complex cyclic stress paths caused by waves. A series of the axial-torsional coupling cyclic loading tests are performed on the saturated marine sands under isotropically consolidated condition by using
Yanshen Wu, Zhirui Zhu, Qi Wu, Gaofeng Xu, Guoxin Chen   +4 more
doaj   +1 more source

Mars Science Helicopter Conceptual Design [PDF]

, 2020
Robotic planetary aerial vehicles increase the range of terrain that can be examined, compared to traditional landers and rovers, and have more near-surface capability than orbiters. Aerial mobility is a promising possibility for planetary exploration as
Balaram, Jayarao, Chan, Athena, Chi, Cheng, Datta, Anubhav, Escobar, Daniel, Fehler, Mireille E., Grip, Havard F., Johnson, Wayne R., Koning, Witold J., Kuang, Winnie, Lumba, Ravi, Malpica, Carlos, Tuano, Allysa Mae B., Tzanetos, Theodore, Withrow, Shannah N., Young, Larry A.   +15 more
core   +1 more source