Results 41 to 50 of about 330,923 (308)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Experimental Study on Cyclic Simple Shear Test of Coastal Tidal Soft Soil

Journal of Marine Science and Engineering
Based on undrained cyclic simple shear tests conducted on coastal tidal soft soil under various conditions of cyclic stress ratios and moisture contents, this study investigated the influence of these factors on the dynamic properties of the soil.
Xiuxia Yu, Honglei Sun, Junwei Liu, Hongxuan Zhao, Yu Han   +4 more
doaj   +1 more source

Pre-fatigue influence on quasi-static tensile properties of Ti-6Al-4V in thin-sheet form [PDF]

, 2010
The response of engineering structures to loads is most often assessed without taking possible damage of the used material(s) into account. However, it has already been proved that a preceding cyclic loading and the alteration of the microstructure it ...
De Baere, Ives, Degrieck, Joris, Galan Lopez, Jesus, Verleysen, Patricia   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Pore-Water Pressure Model for Carbonate Fault Materials Based on Cyclic Triaxial Tests

Frontiers in Earth Science, 2022
Pore-water pressure generation in the saturated carbonate fault zone plays a key role in the initiation of the Daguangbao landslide, which is the largest landslide triggered by the 2008 Wenchuan earthquake in China.
Ling Zhu, Qingwen Yang, Luguang Luo, Luguang Luo, Shenghua Cui   +4 more
doaj   +1 more source

Characterization of the material response in the granular ratcheting [PDF]

, 2005
The existence of a very special ratcheting regime has recently been reported in a granular packing subjected to cyclic loading \cite{alonso04}. In this state, the system accumulates a small permanent deformation after each cycle.
A. Niemunis, C. S. Desai, C. Thornton, D. Kolymbas, F. Alonso-Marroquín, G. L. England, G. Royer-Carfagni, H. J. Herrmann, I. Vardoulakis, J. Burland, J. J. Allen, J. J. Moreau, J. Uzan, L. Brendel, M. Huang, M. Oda, M. P. Allen, P. A. Cundall, R. G. Hicks, R. García-Rojo, S. Werkmeister, S. Zapperi, W. A. Tam, Y. Mroz   +23 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Dissipated energy in undrained cyclic triaxial tests [PDF]

, 2015
Energy-based methods are an emerging tool for the evaluation of liquefaction potential. These methods relate excess pore water pressure build-up to seismic energy dissipated per unit volume.
Azeiteiro, RJN, Coelho, PALF, Grazina, JC, Taborda, DMG   +3 more
core  

Modelling strong seismic ground motion: three-dimensional loading path versus wavefield polarization [PDF]

, 2012
Seismic waves due to strong earthquakes propagating in surficial soil layers may both reduce soil stiffness and increase the energy dissipation into the soil.
D'Avila, Maria Paola Santisi, Lenti, Luca, Semblat, Jean-François   +2 more
core   +6 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source