Results 51 to 60 of about 109,569 (264)

Experimental study on cumulative deformation characteristics of coral sand under long-term cyclic loading

Yantu gongcheng xuebao, 2019
The drained triaxial shear tests on isotropic and K0 consolidation of coral sand samples taken from the South China Sea reveal that the consolidation path has a significant effect on the strength characteristics of the coral sand.
HE Shao-heng 1, LIU Zhi-jun 2, XIA Tang-dai 1, ZHOU Hong-xing 2, YU Bing-qi 1
doaj   +1 more source

Deformation characteristics of saturated remolded loess under cyclic traffic loads

Yantu gongcheng xuebao, 2022
To study the deformation laws of saturated remolded loess under the rotation of principal stress axis, the cyclic triaxial tests and cyclic traffic load tests on the saturated remolded loess under drainage are carried out by using the hollow cylinder ...
WENG Xiao-lin 1, HU Ji-bo 1, JIA Yang 2, ZHOU Shang-qi 1
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Equivalent stress concept to account for the effect of local cyclic stress ratio on transverse cracking in tension–tension fatigue

International Journal of Fatigue
Presented test results on transverse cracking in cross-ply laminates upon tension–tension cyclic loading show that the increase of crack density depends not only on the maximum transverse stress in the cycle but also on the local cyclic stress ratio RTloc in the analyzed layer.
Vivek Richards Pakkam Gabriel, Mohamed Sahbi Loukil, Patrik Fernberg, Janis Varna   +3 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mechanical Behavior Evolution and Damage Characterization of Coal under Different Cyclic Engineering Loading

Geofluids, 2020
The cyclic loading causes the strength change of porous rocks, which can be frequently encountered in underground coal mining. In order to quantify the cumulative damage of porous coal, multilevel uniaxial cyclic compressive tests were carried out ...
Huajun Wang, Jian Li
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Accumulated Deformation of Gravel Filler of Subgrade under Cyclic Loading

工程科学与技术, 2018
Under cyclic loading of the train, the cumulative deformation of the subgrade will be produced, which causes the track irregularity and affects the comfort and safety of the train.
Yangbo LI, Jiasheng ZHANG, Zhihui ZHU, Xuan WANG, Zhaosheng YU   +4 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source