Results 41 to 50 of about 109,321 (266)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Study on Cyclic Simple Shear Test of Coastal Tidal Soft Soil

Journal of Marine Science and Engineering
Based on undrained cyclic simple shear tests conducted on coastal tidal soft soil under various conditions of cyclic stress ratios and moisture contents, this study investigated the influence of these factors on the dynamic properties of the soil.
Xiuxia Yu, Honglei Sun, Junwei Liu, Hongxuan Zhao, Yu Han   +4 more
doaj   +1 more source

Experimental study on cyclic shear stiffness and damping ratio of carbonate sand-steel interface

Rock and Soil Mechanics, 2020
The dynamic response of carbonate sand-steel interface is of great significance to the safety and stability of the structure foundations which are constructed under reef geotechnical conditions.
RUI Sheng-jie, GUO Zhen, WANG Li-zhong, ZHOU Wen-jie, LI Yu-jie   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Research on the Accumulated Plastic Strain of Expansive Soil under Subway Loading

Applied Sciences, 2023
Expansive soil near Hefei Xinqiao International Airport was selected as the research focus. The effects of different loading modes on the dynamic strain of the saturated remodeled expansive soil was investigated by indoor dynamic triaxial tests and the ...
Lei Zhu, Ying Guo, Gan Cheng, Xiangyang Liu   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Post-cyclic strength degradation behavior of soft clay under anisotropic consolidation and numerical simulation

Yantu gongcheng xuebao, 2017
Under the action of cyclic loading of waves, the strength degradation of the soft clay beneath the offshore structures will take place, which will weaken the stability of the upper structure.
WANG Yuan-zhan 1, LEI Ji-chao 1, LI Qing-mei 1, HU Shen-rong 2
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Experimental study on mechanical properties of Xiaojihan coal samples under plastic flow

Meikuang Anquan, 2021
In order to study the plastic flow properties and hysteresis characteristics of Xiaojihan main water-bearing coal seam under the influence of mining, the axial cyclic loading and unloading tests under different confining pressures were carried out. When
YOU Wenqiang, GUO Jingna, WANG Guanghui
doaj   +1 more source