Results 41 to 50 of about 109,569 (264)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Experimental study on cyclic shear stiffness and damping ratio of carbonate sand-steel interface

Rock and Soil Mechanics, 2020
The dynamic response of carbonate sand-steel interface is of great significance to the safety and stability of the structure foundations which are constructed under reef geotechnical conditions.
RUI Sheng-jie, GUO Zhen, WANG Li-zhong, ZHOU Wen-jie, LI Yu-jie   +4 more
doaj   +1 more source

Deformation and cyclic resistance of sand in large-strain undrained torsional shear tests with initial static shear stress

Soils and Foundations, 2021
This paper presents the findings from an experimental study focusing on the undrained cyclic behavior of sand in the presence of initial static shear stress.
Muhammad Umar, Gabriele Chiaro, Takashi Kiyota, Nazish Ullah   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Research on the Accumulated Plastic Strain of Expansive Soil under Subway Loading

Applied Sciences, 2023
Expansive soil near Hefei Xinqiao International Airport was selected as the research focus. The effects of different loading modes on the dynamic strain of the saturated remodeled expansive soil was investigated by indoor dynamic triaxial tests and the ...
Lei Zhu, Ying Guo, Gan Cheng, Xiangyang Liu   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Post-cyclic strength degradation behavior of soft clay under anisotropic consolidation and numerical simulation

Yantu gongcheng xuebao, 2017
Under the action of cyclic loading of waves, the strength degradation of the soft clay beneath the offshore structures will take place, which will weaken the stability of the upper structure.
WANG Yuan-zhan 1, LEI Ji-chao 1, LI Qing-mei 1, HU Shen-rong 2
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experimental study on mechanical properties of Xiaojihan coal samples under plastic flow

Meikuang Anquan, 2021
In order to study the plastic flow properties and hysteresis characteristics of Xiaojihan main water-bearing coal seam under the influence of mining, the axial cyclic loading and unloading tests under different confining pressures were carried out. When
YOU Wenqiang, GUO Jingna, WANG Guanghui
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source