Results 101 to 110 of about 268,296 (309)

Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts [PDF]

, 2010
The integrity of DNA replication control and checkpoint mechanisms is essential for preventing tumorigenesis. DNA replication is initiated by the S-CDK and DDK kinases which mediate the unwinding of the replication fork.
Gold, Daniel A.
core   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Anticancer activity of Elsholtzia winitiana var. dongvanensis Phuong on gastric cancer cells: phytochemical profiling, cell proliferation inhibition, senescence induction, and cell cycle arrest

Beni-Suef University Journal of Basic and Applied Sciences
Background Elsholtzia, a genus within the Lamiaceae family, comprises 42 species predominantly distributed across East and Southeast Asia. Elsholtzia winitiana var. dongvanensis Phuong (EWD) is a subspecies of Elsholtzia winitiana endemic to the Dong Van–
Van Hung Hoang, Thi Thanh Huong Le, Phu Hung Nguyen, Duy Hung Nguyen, Quang Tan Luc, Thi Kieu Oanh Nguyen, Khac Hung Do   +6 more
doaj   +1 more source

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

The role of anchorage in cell cycle control

, 2009
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint ...
Cremona, C.A.
core  

Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]

, 2005
Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates

, 2010
The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several phases,
Sadowski, Martin, Sarcevic, Boris, Suryadinata, Randy   +2 more
core   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source