Results 311 to 320 of about 504,196 (405)

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Aging Cell, EarlyView.
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu, Di Fan, Hai‐peng Wu, Xiao‐yi Hu, Qiu‐li He, Xin‐miao Wu, Cui‐na Shi, Jian‐jun Yang, Mu‐huo Ji   +8 more
wiley   +1 more source

Spatiotemporal Orchestration of Mitosis by Cyclin-Dependent Kinase

Kapadia N, Nurse P.
europepmc   +1 more source

A Retrospective Tribute to Dr. Harish Pant (1938-2023) and His Seminal Work on Cyclin Dependent Kinase 5. [PDF]

Neurochem Res
Hall B, Amin N, Veeranna, Hisanaga SI, Kulkarni AB.   +4 more
europepmc   +1 more source

Effect of aging on the development and progression of alcohol‐associated liver disease

Alcohol, Clinical and Experimental Research, EarlyView.
Age is a predictor for alcohol‐associated liver disease (ALD)‐related mortality. This study investigates the effects of aging on the ethanol‐induced development and progression of ALD in rats. This study demonstrates that chronic ethanol feeding increased liver injury markers and hepatic triglycerides across all age groups.
Ramesh Bellamkonda, Sundararajan Mahalingam, Ojeshvi Ethiraj, Sathish Kumar Perumal, Madan Kumar Arumugam, Daren L. Knoell, Kurt W. Fisher, Carol A. Casey, Kusum K. Kharbanda, Karuna Rasineni   +9 more
wiley   +1 more source

Timing of Dose Reductions and Survival Outcomes in Metastatic Breast Cancer Patients Treated with Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

Curr Oncol
Kubilay Tolunay P, Kurt İnci B, Usta Ş, Topkaç A, Karabuğa B, Aydemir E, Öner İ, Akay Hacan B, Ateş Ö, Karaçin C, Yalçıntaş Arslan Ü.   +10 more
europepmc   +1 more source

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

Brain Pathology, EarlyView.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez, Muhammad Nadeem, Bin He, Jennifer C. Miguel, David G. Moreno, Marta Moreno‐Rodriguez, Michael Malek‐Ahmadi, Chadwick M. Hales, Elliott J. Mufson   +8 more
wiley   +1 more source

Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. [PDF]

Hum Cell
Hoshino H, Akama TO, Inoue D, Moritani S, Shigeto S, Matsuda K, Yoshida H, Yonemoto N, Fukushima M, Yoshida Y, Kobayashi M.   +10 more
europepmc   +1 more source

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

Cancer Science, EarlyView.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source

Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study. [PDF]

Medicina (Kaunas)
Doğan A, İlhan N, Akdağ G, Yıldırım S, Seyyar M, Yüksel Yaşar Z, Erölmez HN, Sürmeli H, Öztosun B, Sever ÖN, Odabaş H, Yıldırım ME, Çabuk D, Turan N, Gümüş M.   +14 more
europepmc   +1 more source

NFATc4 Promotes Lung Adenocarcinoma Progression via the CCNB1/CDK1 Pathway and Is a Potential Prognostic Biomarker

Cancer Science, EarlyView.
NFATc4 is upregulated in LUAD, and its high expression correlates with the malignant progression of patients. NFATc4 enhances LUAD cell viability and proliferation by regulating the G2/M phase transition and apoptosis. Functionally, NFATc4 directly binds to the CCNB1 promoter, modulating the CCNB1/CDK1 pathway, which results in cell cycle arrest and ...
Wendi Yang, Xue Wu, Fanghao Cai, Zhengjun Guo, Zaicheng Xu, Yuan Peng, Zhenzhou Yang, Xiaoyue Zhang   +7 more
wiley   +1 more source