Results 291 to 300 of about 550,507 (355)

Cyclin‐Dependent Kinase 12, Immunity, and Prostate Cancer

New England Journal of Medicine, 2018
Prostate Cancer and Checkpoint Inhibition Somatic inactivating variants in the gene CDK12, encoding cyclin-dependent kinase 12, generate fusion-induced neoantigens in prostate cancer.
E. Antonarakis
semanticscholar   +1 more source

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

Molecular Cancer Therapeutics, 2004
PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50, 0.011 micromol/L) and Cdk6 (IC50, 0.016 micromol/L), having no activity against a panel of 36 additional protein kinases.
D. W. Fry, P. Harvey, P. Keller, W. Elliott, M. Meade, E. Trachet, M. Albassam, Xianxian Zheng, W. Leopold, N. Pryer, P. Toogood   +10 more
semanticscholar   +1 more source

Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology, 1996
The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function ...
openaire   +2 more sources

Cyclin dependent kinase regulation

Current Opinion in Cell Biology, 1995
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and their activities are consequently tightly regulated. Recent developments in the field of CDK regulation have included the discovery and characterization of CDK inhibitors. These developments have had an impact on our understanding of how other signalling pathways may be linked to ...
openaire   +2 more sources

Cyclin-dependent kinases and stroke

Expert Opinion on Therapeutic Targets, 2001
Cyclin-dependent kinases (CDKs) are a group of enzymes predominately known for their role in cell cycle regulation in proliferating cell types. Increasing evidence, however, suggests that CDKs also promote death in neurones. These observations have lead to the notion that CDKs may serve as a therapeutic target for neuropathological conditions such as ...
Fuhu, Wang, Michael J, O'Hare, David S, Park   +2 more
openaire   +2 more sources

Cyclin-Dependent Kinases

Chemical Reviews, 2001
J W, Harper, P D, Adams
openaire   +3 more sources

Measuring Cyclin-Dependent Kinase Activity

2004
The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
openaire   +2 more sources

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.

Cell, 1994
K. Polyak, Mong Hong Lee, H. Erdjument‐Bromage, A. Koff, James M. Roberts, P. Tempst, J. Massagué   +6 more
semanticscholar   +1 more source

Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors

2023
Nathan H. Lents, Richard T. Piszczatowski   +1 more
openaire   +1 more source

Cyclin-dependent protein kinases

2000
Abstract Cyclin-dependent protein kinases (Cdks) regulate progression through the eukaryotic cell cycle. They are also involved in the regulation of other processes such as gene expression and phosphate metabolism. Cdks are the catalytic subunits of hetero dimeric complexes and they approximate the size of a minimal protein-kinase ...
openaire   +1 more source