Results 281 to 290 of about 550,507 (355)

The Cyclin-Dependent Kinase activity modulates the central carbon metabolism in maize during germination. [PDF]

Physiol Plant
Lara-Núñez A, Garza-Aguilar SM, Páez-Franco JC, de Dios Galindo-de-la-Rosa J, Vallejo-Becerra V.   +4 more
europepmc   +1 more source

Therapeutic Challenges in the Use of Chemotherapy and Cyclin-Dependent Kinase 4/6 Inhibitors in a Patient With Charcot-Marie-Tooth Disease and Breast Cancer. [PDF]

Cureus
Mota Araújo P, Cunha R, Sousa M.
europepmc   +1 more source

Real-World Plasma Thymidine Kinase Activity in High-Risk and Metastatic Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Treated With Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

JCO Precis Oncol
O'Connor TN, Schultz E, Kabraji S, Levine E, Williams AJ, Knudsen ES, Witkiewicz AK.   +6 more
europepmc   +1 more source

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains

Otani Y, Goodall E, Srinivasan V, Ball NJ, Barnett SFH, Zech T, Saarikangas J, Goult BT.   +7 more
europepmc   +1 more source

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Cyclin-dependent kinase 4 and 6 inhibitors for hormone receptor-positive breast cancer: past, present, and future.

The Lancet, 2020
The development and approval of cyclin-dependent kinase (CDK) 4 and 6 inhibitors for hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer represents a major milestone in cancer therapeutics ...
Laura M. Spring, Seth A. Wander, F. André, B. Moy, N. Turner, A. Bardia   +5 more
semanticscholar   +1 more source

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +5 more sources

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences, 2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell ...
Marcos, Malumbres, Mariano, Barbacid
openaire   +2 more sources

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Pharmacological Research, 2019
Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle.
R. Roskoski
semanticscholar   +1 more source

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.

Journal of Medicinal Chemistry, 2018
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Although
S. Tadesse, E. Caldon, W. Tilley, Shudong Wang   +3 more
semanticscholar   +1 more source

Cdk Pathway: Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors

Molecular Biotechnology, 2001
Many mechanisms either activate or inhibit the cdks and thereby either promote or arrest progression through the mitotic cell cycle. Since the signal transduction pathways emanating from extracellular mitogens and the agents controlling these pathways are complicated there may yet be novel mechanisms of cell cycle regulation remaining to be elucidated.
D M, Gitig, A, Koff
openaire   +3 more sources