Results 261 to 270 of about 268,296 (309)

Cyclin-dependent kinases and stroke

Expert Opinion on Therapeutic Targets, 2001
Cyclin-dependent kinases (CDKs) are a group of enzymes predominately known for their role in cell cycle regulation in proliferating cell types. Increasing evidence, however, suggests that CDKs also promote death in neurones. These observations have lead to the notion that CDKs may serve as a therapeutic target for neuropathological conditions such as ...
Fuhu, Wang, Michael J, O'Hare, David S, Park   +2 more
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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors in the Mouse Nervous System

Molecular Neurobiology, 2020
Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying
Alice Grison, Suzana Atanasoski
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Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology, 1996
The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function ...
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Expression of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors in oligodendrogliomas in humans

Neuroscience Letters, 2003
Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
Valentina, Fiano, Chiara, Ghimenti, Davide, Schiffer   +2 more
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Inhibitors of cyclin-dependent kinase and cancer

Journal of Molecular Medicine, 1995
Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
J R, Biggs, A S, Kraft
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Designing Inhibitors of Cyclin-Dependent Kinases

Annual Review of Pharmacology and Toxicology, 2002
Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Ian R, Hardcastle, Bernard T, Golding, Roger J, Griffin   +2 more
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Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
S K, Jain, S B, Bharate, R A, Vishwakarma   +2 more
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Quinazolines as cyclin dependent kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2001
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
T M, Sielecki, T L, Johnson, J, Liu, J K, Muckelbauer, R H, Grafstrom, S, Cox, J, Boylan, C R, Burton, H, Chen, A, Smallwood, C H, Chang, M, Boisclair, P A, Benfield, G L, Trainor, S P, Seitz   +14 more
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Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A, Ubersax, Erika L, Woodbury, Phuong N, Quang, Maria, Paraz, Justin D, Blethrow, Kavita, Shah, Kevan M, Shokat, David O, Morgan   +7 more
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Identification of substrates for cyclin dependent kinases

Advances in Enzyme Regulation, 2010
Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes. From yeast to humans, cell cycle progression and cell division require the activation of a group of serine– threonine protein kinases called cyclin dependent kinases (CDKs) (Morgan, 1997), which initiate and coordinate these processes by orderly phosphorylation ...
Errico, A., Deshmukh, K., Tanaka, Y., Pozniakovsky, A., Hunt, T.   +4 more
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