Results 251 to 260 of about 268,296 (309)

Continuing Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Advanced Breast Cancer: A Meta-Analysis. [PDF]

Cancers (Basel)
Pathak N, Kumar S, Gimenez DM, Di Iorio M, Savill J, Berner-Wygoda Y, Li M, Valiente CM, Cuthbert D, Gupta A, Arteaga DP, Batra A, Amir E, Mittal A.   +13 more
europepmc   +1 more source

Toxicity profiles of cyclin-dependent kinase 4/6 inhibitors: safety analysis from clinical trials and the FDA adverse event reporting system. [PDF]

Front Oncol
Zhou J, Lin X, Wang S, Xie M, Hu X, Cai J.   +5 more
europepmc   +1 more source

Cyclin dependent kinase 9 inhibitor induces transcription-replication conflicts and DNA damage accumulation in breast cancer. [PDF]

Cancer Cell Int
Lee M, Lee KH, Min A, Kim SH, Ham S, Hwang HM, Noh Y, Kim YJ, Lee DW, Koh J, Im SA.   +10 more
europepmc   +1 more source

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains

Otani Y, Goodall E, Srinivasan V, Ball NJ, Barnett SFH, Zech T, Saarikangas J, Goult BT.   +7 more
europepmc   +1 more source

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Cyclin dependent kinase regulation

Current Opinion in Cell Biology, 1995
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and their activities are consequently tightly regulated. Recent developments in the field of CDK regulation have included the discovery and characterization of CDK inhibitors. These developments have had an impact on our understanding of how other signalling pathways may be linked to ...
Emma Lees
exaly   +3 more sources

The dynamics of cyclin dependent kinase structure

Current Opinion in Cell Biology, 1996
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
David O Morgan
exaly   +3 more sources

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
G Sass, Alexander G Khandoga, Jos Joore   +2 more
exaly   +2 more sources

Cdk Pathway: Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors

Molecular Biotechnology, 2001
Many mechanisms either activate or inhibit the cdks and thereby either promote or arrest progression through the mitotic cell cycle. Since the signal transduction pathways emanating from extracellular mitogens and the agents controlling these pathways are complicated there may yet be novel mechanisms of cell cycle regulation remaining to be elucidated.
D M, Gitig, A, Koff
openaire   +3 more sources

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +5 more sources

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences, 2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell ...
Marcos, Malumbres, Mariano, Barbacid
openaire   +2 more sources