Results 231 to 240 of about 3,489,964 (290)

Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression. [PDF]

Cancer Commun (Lond)
Huang J, Larsson P, Kakay Afshari M, Tejera Nevado P, Tešan Tomić T, Fehr A, Jäwert F, Stenman G, Andersson MK.   +8 more
europepmc   +1 more source

An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure. [PDF]

Front Aging Neurosci
Luo D, Lian T, Wei N, Guo P, He M, Zhang Y, Huang Y, Liu G, Li J, Li J, Qi J, Guan H, Zhang W, Zhang W, Zheng Z, Yue H, Liu Z, Zhang F, Meng Y, Zhang W.   +19 more
europepmc   +1 more source

PAK4 phosphorylates cyclin-dependent kinase 2 to promote the G₁/S transition during adipogenesis. [PDF]

Exp Mol Med
Yu HC, Park SH, Jo HJ, Sim H, Lee MR, Kim G, Park SY, Lee Y, Bae EJ, Park BH.   +9 more
europepmc   +1 more source

Correction to: Phase I trial of SPH4336, a novel cyclin-dependent kinase 4/6 inhibitor, in patients with advanced solid tumors. [PDF]

Oncologist
europepmc   +1 more source

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Cyclin Dependent Kinase Regulation

Current Opinion in Cell Biology, 1995
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and their activities are consequently tightly regulated. Recent developments in the field of CDK regulation have included the discovery and characterization of CDK inhibitors. These developments have had an impact on our understanding of how other signalling pathways may be linked to ...
E Lees, Emma Lees
exaly   +3 more sources

The Discovery of Cyclin-Dependent Kinases

Nature Reviews Molecular Cell Biology
Paul Nurse
exaly   +3 more sources

Cdk Pathway: Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors

Molecular Biotechnology, 2001
Many mechanisms either activate or inhibit the cdks and thereby either promote or arrest progression through the mitotic cell cycle. Since the signal transduction pathways emanating from extracellular mitogens and the agents controlling these pathways are complicated there may yet be novel mechanisms of cell cycle regulation remaining to be elucidated.
D M, Gitig, A, Koff
openaire   +3 more sources

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences, 2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell ...
Marcos, Malumbres, Mariano, Barbacid
openaire   +2 more sources

Cyclin-dependent kinases and stroke

Expert Opinion on Therapeutic Targets, 2001
Cyclin-dependent kinases (CDKs) are a group of enzymes predominately known for their role in cell cycle regulation in proliferating cell types. Increasing evidence, however, suggests that CDKs also promote death in neurones. These observations have lead to the notion that CDKs may serve as a therapeutic target for neuropathological conditions such as ...
Fuhu, Wang, Michael J, O'Hare, David S, Park   +2 more
openaire   +2 more sources

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +5 more sources