Results 211 to 220 of about 268,841 (309)

Efficacy and Predictability of Cyclin-Dependent Kinase 4/6 Inhibitors in HER2-Positive Breast Cancer. [PDF]

Cancers (Basel)
Abbasi MS, Afzal MZ, Sarwar T, Gamlen-Steves HA.   +3 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure. [PDF]

Front Aging Neurosci
Luo D, Lian T, Wei N, Guo P, He M, Zhang Y, Huang Y, Liu G, Li J, Li J, Qi J, Guan H, Zhang W, Zhang W, Zheng Z, Yue H, Liu Z, Zhang F, Meng Y, Zhang W.   +19 more
europepmc   +1 more source

Alterations in MicroRNA and Cytokine Expressions in Placental and Amniotic Tissues of COVID‐19 Affected Pregnant Women

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Since 2019, coronavirus disease 2019 (COVID‐19) has been associated with increased risks of preterm birth and placental complications. We prospectively investigated alterations in microRNAs (miRNAs) and cytokines in placental and amniotic tissues from pregnant women with and without COVID‐19 to evaluate the infection's impact on pregnancy ...
Wei‐Chun Chen, Shu‐Yu Hu, Chao‐Min Cheng, Ching‐Ju Shen   +3 more
wiley   +1 more source

Pan-cyclin-dependent kinase inhibition is a potential treatment for adenoid cystic carcinoma that downregulates the MYB::NFIB fusion and induces tumor regression. [PDF]

Cancer Commun (Lond)
Huang J, Larsson P, Kakay Afshari M, Tejera Nevado P, Tešan Tomić T, Fehr A, Jäwert F, Stenman G, Andersson MK.   +8 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer's Disease. [PDF]

Biomolecules
Kumari S, Singh AK, Kumar M, Pradhan R, Rao AR, Yadav Y, Kumar P, Haldar P, Kaur P, Dey S.   +9 more
europepmc   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

PAK4 phosphorylates cyclin-dependent kinase 2 to promote the G₁/S transition during adipogenesis. [PDF]

Exp Mol Med
Yu HC, Park SH, Jo HJ, Sim H, Lee MR, Kim G, Park SY, Lee Y, Bae EJ, Park BH.   +9 more
europepmc   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source