Results 191 to 200 of about 550,507 (355)

Cyclin dependent kinase (CDK) [PDF]

Science-Business eXchange, 2010
openaire   +2 more sources

The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer. [PDF]

J Biol Chem
Zhu M, Huang L, Sun S, Chen M, Cai J, Zhang Y, Wang L, Cai L, Peng M.   +8 more
europepmc   +1 more source

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature reviews. Drug discovery, 2015
U. Asghar, A. Witkiewicz, N. Turner, E. Knudsen   +3 more
semanticscholar   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor-Sensitive Cells-of-Origin in Esophageal Squamous Cell Carcinoma. [PDF]

Gastro Hep Adv
Ko KP, Zhang J, Jun S, Park JI.
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin-Dependent Kinase 4 Inhibitors. [PDF]

ChemistryOpen
Abolibda TZ, Al-Hussain SA, Farag B, El-Naggar M, Zaki MEA, Alhazmi ESA, Almohammadi ASM, Gomha SM.   +7 more
europepmc   +1 more source

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

Proceedings of the National Academy of Sciences of the United States of America, 1995
M. Datto, Yan Li, J. Panus, David J. Howe, Y. Xiong, Xiao-Fan Wang   +5 more
semanticscholar   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Mitotic entry is controlled by the plant-specific phosphatase BSL1 and cyclin-dependent kinase B. [PDF]

Nat Plants
Tulin F, Aizezi Y, Reyes AV, Fujieda Y, Grossman A, Xu SL, Onishi M, Assaad FF, Wang ZY.   +8 more
europepmc   +1 more source