Results 181 to 190 of about 268,841 (309)

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling. [PDF]

Nat Commun
Ye S, Zhao Y, Tu H, Han X, Liu T, Gong Y, Lu J, Jin T, Luo W, Qu X, Lai D, Fu G, Liang G.   +12 more
europepmc   +1 more source

SUDEP and mortality in developmental and epileptic encephalopathies: A meta‐analysis of randomized clinical trials and extension studies

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are associated with high premature mortality and increased risk of sudden unexpected death in epilepsy (SUDEP). However, epidemiological data remain limited, particularly for specific syndromes such as Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and infantile epileptic ...
Pierludovico Moro, Maria Sole Borioni, Adolfo Mazzeo, Enrico Cocchi, Carlo Di Bonaventura, Emanuele Cerulli Irelli   +5 more
wiley   +1 more source

Cyclin-dependent kinase inhibitor-1 deficiency enhances bone destruction in a mouse model of arthritis. [PDF]

Bone Rep
Wada K, Hayashi S, Onoi Y, Tachibana S, Suda Y, Saito A, Maeda T, Araki S, Motono K, Kamenaga T, Tsubosaka M, Kuroda Y, Nakano N, Matsumoto T, Kuroda R.   +14 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Impact of Cyclin-dependent Kinase Inhibitor 1A Genotypes on Prostate Cancer Susceptibility Prediction. [PDF]

In Vivo
Liao CH, Bau DT, Wang BR, Chang SY, Hsia TC, Lee HT, Chen JC, Huang WC, Tsai CW, Wang YC, Shih HY, Chang WS.   +11 more
europepmc   +1 more source

Deciphering the role of Ki67: prognostic insights in advanced breast cancer therapy with Cyclin-dependent kinase 4/6 inhibitors. [PDF]

BMC Cancer
Kubeczko M, Polakiewicz-Gilowska A, Świderska K, Mianowska-Malec M, Leśniak A, Łanoszka B, Chomik K, Grandys B, Lisovska N, Woźniak G, Latusek T, Stobiecka E, Simek J, Pyciński B, Bobek-Billewicz B, Chmielik E, Jarząb M.   +16 more
europepmc   +1 more source

Preclinical Evaluation of the Efficacy of the Cyclin-Dependent Kinase Inhibitor Ribociclib in Combination with Letrozole against Patient-Derived Glioblastoma Cells. [PDF]

Mol Cancer Ther
Gadgil SN, Karve AS, Gudelsky GA, Gabani BB, Kulkarni SP, Phoenix TN, Medvedovic M, Plas DR, Wise-Draper TM, Sengupta S, DasGupta B, Yogendran L, Desai PB.   +12 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin-Dependent Kinase 4 Inhibitors. [PDF]

ChemistryOpen
Abolibda TZ, Al-Hussain SA, Farag B, El-Naggar M, Zaki MEA, Alhazmi ESA, Almohammadi ASM, Gomha SM.   +7 more
europepmc   +1 more source