Results 161 to 170 of about 550,507 (355)

Underutilization of syndrome‐specific ICD‐10 codes for genetic epilepsies: Implications for precision medicine

Epilepsia, EarlyView.
Abstract Syndrome‐specific International Classification of Diseases, 10th Revision (ICD‐10) codes have the potential to improve identification of patients for precision therapies, clinical trials, and research, yet their real‐world uptake is not well characterized.
Émile Moura Coelho da Silva, Tobias Brünger, Gary Taylor, Mousumi Sinha, Alison Merket, Anu Cherukara, Sunanjay Bajaj, Jessica Clark, Ludovica Montanucci, Emily A. Huth, Mariana Fauteux, Samden D. Lhatoo, Christian M. Boßelmann, Costin Leu, Rahil A. Tai, Dennis Lal   +15 more
wiley   +1 more source

Mental health impacts experienced by caregivers of people with Dravet syndrome: A systematic literature review

Epilepsia, EarlyView.
Graphical abstract for the systematic literature review. Abstract Objective Dravet syndrome (DS) places tremendous burden on caregivers owing to the extent of required assistance and impact on daily living, as well as the risk to the individual with DS of premature mortality from sudden unexpected death in epilepsy and morbidity associated with ...
Adam Strzelczyk, Mary Anne Meskis, Galia Wilson, Bobby Jacob, Christoph Helmstaedter, Jane von Gaudecker, Veronica Hood, Ceri Hughes, Michael Scott Perry   +8 more
wiley   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Spatiotemporal orchestration of mitosis by cyclin-dependent kinase. [PDF]

Nature
Kapadia N, Nurse P.
europepmc   +2 more sources

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, EarlyView.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Metastatic Cutaneous Adnexal Carcinoma of the Head and Neck With Durable Response to an Aromatase Inhibitor Combined With a Cyclin‐Dependent Kinase 4/6 Inhibitor

Head &Neck, EarlyView.
ABSTRACT Background Cutaneous adnexal carcinomas are a very rare group of cancers arising from appendageal structures of the skin. More than half occur in the head and neck region. No standard treatments exist for metastatic disease. Methods A 48‐year‐old postmenopausal female presented with an enlarging scalp lesion.
Nilesh Kapoor, Manasa Narasimman, Travis Vandergriff, Amy L. Jones   +3 more
wiley   +1 more source

Loss of cyclin-dependent kinase-like 5 results in susceptibility to audiogenic seizures in mice. [PDF]

Epilepsia Open
Higgins J, Egan S, El-Mansoury B, Henshall DC, Mamad O.   +4 more
europepmc   +1 more source

Methyl-cantharidimide suppresses cyclin-dependent kinase 1 (CDK1) and induces oxeiptosis in liver cancer. [PDF]

J Exp Clin Cancer Res
Li YD, Chen X, Dong XD, Ding Z, Chen ZS, Fang S.   +5 more
europepmc   +1 more source

D-type cyclin-dependent kinase activity in mammalian cells

Molecular and Cellular Biology, 1994
H. Matsushime, D. Quelle, S. Shurtleff, M. Shibuya, C. Sherr, J. Kato   +5 more
semanticscholar   +1 more source