Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm
Gut Medicine, EarlyView.ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang +5 more
wiley +1 more source
Pyridine Derivatives as Cyclin-Dependent Kinase Inhibitors for the Treatment of Cancer. [PDF]
ACS Med Chem LettJiang Y, Liang SH.
europepmc +1 more source
Synthesis of the small peptide analogues of cyclin dependent kinase (CDK4) for cancer treatment
Cyclin-dependent kinases (CDKs) are a group of enzymes that are involved in cell cycle progression regulation. The CDKs activate host proteins through phosphorylation on serine or threonine using adenosine triphosphate as a phosphate donor.
Romsaiyud, Jariya
core +1 more source
A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999-2025). [PDF]
Front Bioeng BiotechnolDerzhavina VM +2 more
europepmc +1 more source
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated ...
Boyle FT +5 more
core +3 more sources
Inhibition of Cyclin-dependent Kinase Counteracts Neuron-promoted Bladder and Endometrial Tumorigenesis: A Systematic Analysis. [PDF]
In VivoWang MH, Pan MR, Hung YH.
europepmc +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
An Integrated Computational Workflow for Discovering Alkaloid-Derived Ligands of Cyclin-Dependent Kinase 2. [PDF]
Pharmaceuticals (Basel)Do AT, Pham QL, Phung HTT, Pham MQ.
europepmc +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Local recurrence after primary breast cancer treatment remains a complex clinical scenario in patients previously treated with breast‐conserving therapy and radiotherapy. For decades, salvage mastectomy was considered the standard treatment for ipsilateral breast tumor recurrence, largely because of concerns about local control after repeat ...
Cezara Cheptea +4 more
wiley +1 more source
Alternative Splicing in Cyclin-Dependent Kinase 4/6 Inhibitor Resistance in Estrogen Receptor-Positive Breast Cancer. [PDF]
Drug Dev ResCui Y +6 more
europepmc +1 more source