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Pharmacological inhibitors of cyclin-dependent kinases
Trends in Pharmacological Sciences, 2002Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. Deregulation of CDKs in various diseases has stimulated an intensive search for selective pharmacological inhibitors of these kinases.
Marie, Knockaert +2 more
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Cyclins, cyclin‐dependent kinases and differentiation
BioEssays, 1997AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
C Y, Gao, P S, Zelenka
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Chemical inhibitors of cyclin-dependent kinases
Trends in Cell Biology, 1995The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
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p27KIP1, an inhibitor of cyclin-dependent kinases
1995The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
A, Koff, K, Polyak
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Targets of cyclin-dependent protein kinases
Current Opinion in Cell Biology, 1993Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.
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Smad3 phosphorylation by cyclin-dependent kinases
Cytokine & Growth Factor Reviews, 2006Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors
2023Nathan H. Lents +1 more
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Measuring Cyclin-Dependent Kinase Activity
2004The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
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