Results 71 to 80 of about 268,841 (309)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The role of anchorage in cell cycle control [PDF]
, 2009 Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint ...
Cremona, C.A.
core
Cell Division, 2008 Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286 ...
Diehl J Alan, Pontano Laura L
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates [PDF]
, 2010 The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several phases,
Sadowski, Martin +2 more
core +1 more source
A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Plant Direct, 2023 Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes.
Sorin Tanasa +10 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
core +1 more source
CDK12/CDK13: New Hope for Targeted Therapy of Human Malignant Tumors
Zhongliu Fangzhi YanjiuCell cycle turnover depends on cyclin-dependent kinase (CDKs). CDK is the protein kinase family that plays the key role in regulating cell cycle and gene transcription.
CHEN Kaixing, WU Zhouying, YU Lan
doaj +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source