Results 151 to 160 of about 805,965 (369)

Roscovitine Modulates DNA Repair and Senescence: Implications for Combination Chemotherapy [PDF]

, 2005
PURPOSE: Treatment of tumor cells by chemotherapy activates a series of responses ranging from apoptosis to premature senescence and repair. Survival responses are characterized by inhibition of cyclin-dependent kinases.
BRADY HJ, CRESCENZI E, G. PALUMBO
core   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells

Molecules, 2017
Colorectal cancer is a leading cause of death worldwide and occurs through the highly complex coordination of multiple cellular pathways, resulting in carcinogenesis.
Sung-Suk Suh, Tai Kyoung Kim, Jung Eun Kim, Ju-Mi Hong, Trang Thu Thi Nguyen, Se Jong Han, Ui Joung Youn, Joung Han Yim, Il-Chan Kim   +8 more
doaj   +1 more source

Role of the Cyclin-Dependent Kinase Inhibitor p27^Kip1in Androgen-Induced Inhibition of CAMA-1 Breast Cancer Cell Proliferation [PDF]

, 2001
Jacques Lapointe, Claude Labrie
openalex   +2 more sources

Repurposing a Cyclin-Dependent Kinase 1 (CDK1) Mitotic Regulatory Network to Complete Terminal Differentiation in Lens Fiber Cells. [PDF]

Invest Ophthalmol Vis Sci, 2023
Taylor A, Gu Y, Chang ML, Yang W, Francisco S, Rowan S, Bejarano E, Pruitt S, Zhu L, Weiss G, Brennan L, Kantorow M, Whitcomb EA.   +12 more
europepmc   +1 more source

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication [PDF]

, 2011
Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts.
Dunphy, William G., Kumagai, Akiko, Shevchenko, Andrej, Shevchenko, Anna   +3 more
core   +2 more sources

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing

Advanced Science, EarlyView.
A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding, Jinglin Wang, Jiaye Li, Yi Cheng, Shuyin Zhou, Yepeng Zhang, Yuanjin Zhao, Min Zhou   +7 more
wiley   +1 more source

Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein [PDF]

, 1999
Lene E. Johannessen, Sigrun L. Knardal, Inger Helene Madshus   +2 more
openalex   +1 more source

HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death. [PDF]

Viruses, 2022
Saro A, Gao Z, Kambey PA, Li M, Huang J.
europepmc   +1 more source

Expressionsanalyse von Aurora-Kinase A, Aurora-Kinase B, Repp 86, Cyclin-Dependent-Kinase 1 und Cyclin-Dependent-Kinase 2 bei Mamma- und Ovarialkarzinomen [PDF]

, 2014
Expressionsanalyse von Aurora-Kinase A, Aurora-Kinase B, Repp 86, Cyclin-Dependent-Kinase 1 und Cyclin-Dependent-Kinase 2 bei Mamma- und ...
Dittmann, Linda
core