Results 201 to 210 of about 805,965 (369)

An open‐label, single‐arm, multicenter, phase II trial of bireociclib as monotherapy for heavily pretreated HR‐positive, HER2‐negative advanced breast cancer patients: BRIGHT‐1 trial

Cancer Communications, EarlyView.
Abstract Background Bireociclib (XZP‐3287) is a novel selective cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies. BRIGHT‐1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced, recurrent or metastatic, hormone ...
Jiayu Wang, Qingyuan Zhang, Tao Sun, Huiping Li, Ying Cheng, Zhongsheng Tong, Huihui Li, Wei Li, Jingfen Wang, Yuee Teng, Xinhong Wu, Jing Cheng, Zhendong Chen, Zhengqiu Zhu, Li Wang, Mingming Liu, Xianghui Duan, Lingmei Xu, Binghe Xu   +18 more
wiley   +1 more source

Cyclooxygenase-2 Overexpression Inhibits Platelet-derived Growth Factor-induced Mesangial Cell Proliferation through Induction of the Tumor Suppressor Gene p53 and the Cyclin-dependent Kinase Inhibitors p21waf-1/cip-1 and p27kip-1 [PDF]

, 2002
Gunther Zahner, Günter Wolf, Murwan Ayoub, Rüdiger Reinking, Ulf Panzer, Stuart J. Shankland, Rolf A.K. Stahl   +6 more
openalex   +1 more source

A phase II basket trial of dual anti‐CTLA‐4 and anti‐PD‐1 blockade in rare tumors (DART) SWOG S1609: durable responses and delayed pseudoprogression in small cell carcinoma of the ovary, hypercalcemic type cohort

Cancer Communications, EarlyView.
Abstract Background The combined use of anti‐programmed cell death protein 1 (PD‐1)/anti‐cytotoxic T‐lymphocyte associated protein 4 (CTLA‐4) checkpoint inhibitors has been effective in various cancer types. The Southwest Oncology Group (SWOG) Dual Anti‐CTLA‐4 and Anti‐PD‐1 Blockade in Rare Tumors (DART) S1609 study investigated ipilimumab and ...
Young Kwang Chae, Megan Othus, Sandip Pravin Patel, Raid Aljumaily, Khine Z. Win, Tanya Pejovic, Sajeve S. Thomas, William R. Robinson III, Hye Sung Kim, Liam Il‐Young Chung, Christine M. McLeod, Helen X. Chen, Elad Sharon, Howard Streicher, Christopher W. Ryan, Charles D. Blanke, Razelle Kurzrock   +16 more
wiley   +1 more source

Inhibition of Cyclin-Dependent Kinase 1 by Purines and Pyrrolo[2,3-d]Pyrimidines Does Not Correlate with Antiviral Activity [PDF]

, 2002
David L. Evers, Julie M. Breitenbach, Katherine Z. Borysko, Leroy B. Townsend, John C. Drach   +4 more
openalex   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source

Cell-Free Degradation of p27^kip1, a G₁ Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

, 1999
Hoang M. Nguyen, Diana M. Gitig, Andrew Koff   +2 more
openalex   +1 more source

The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca²⁺/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner [PDF]

, 2002
Rani Dhavan, Paul L. Greer, Maria A. Morabito, Lianna Orlando, Li‐Huei Tsai   +4 more
openalex   +1 more source

Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC). [PDF]

Cancers (Basel), 2021
Wijnen R, Pecoraro C, Carbone D, Fiuji H, Avan A, Peters GJ, Giovannetti E, Diana P.   +7 more
europepmc   +1 more source

Expression of Cyclin-Dependent Kinase Inhibitor p27Kip1 in AIDS-Related Diffuse Large-Cell Lymphomas Is Associated with Epstein-Barr Virus-Encoded Latent Membrane Protein 1 [PDF]

, 2002
Annunziata Gloghini, Gianluca Gaïdano, Luigi Maria Larocca, Francesco Pierconti, Antonella Cingolani, Luigino Dal Maso, Daniela Capello, Silvia Franceschi, Umberto Tirelli, Massimo Libra, Huifeng Niu, Riccardo Dalla‐Favera, Antonino Carbone   +12 more
openalex   +1 more source

A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells. [PDF]

Molecules, 2021
Pecoraro C, Parrino B, Cascioferro S, Puerta A, Avan A, Peters GJ, Diana P, Giovannetti E, Carbone D.   +8 more
europepmc   +1 more source