Results 251 to 260 of about 109,030,997 (289)

Molecular models of cyclin-dependent kinase 1 complexed with inhibitors

Biochemical and Biophysical Research Communications, 2004
Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). The structures of CDK2 complexed with roscovitine and deschoroflavopiridol have been reported, however no crystallographic structure is available for complexes of CDK1 with inhibitors.
Canduri, F., Uchoa, H. B., de Azevedo, W. F.   +2 more
openaire   +3 more sources

Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors

Molecular and Cellular Biochemistry, 2002
HTLV-1 is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), where viral replication and transformation are largely dependent upon modification of regulatory and host cell cycle proteins.
Lai, Wang, Longwen, Deng, Kaili, Wu, Cynthia, de la Fuente, Dai, Wang, Kylene, Kehn, Anil, Maddukuri, Shanese, Baylor, Francisco, Santiago, Emmanuel, Agbottah, Sylviane, Trigon, Michel, Morange, Renaud, Mahieux, Fatah, Kashanchi   +13 more
openaire   +2 more sources

3D-QSAR CoMFA Study on Oxindole Derivatives as Cyclin Dependent Kinase 1 (CDK1) and Cyclin Dependent Kinase 2 (CDK2) Inhibitors

Medicinal Chemistry, 2007
Cyclin dependent kinases have emerged as important drug targets with a multitude of therapeutic potentials for their inhibitors. With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA
Sanjeev Kumar, Singh, Nigus, Dessalew, Prasad V, Bharatam   +2 more
openaire   +2 more sources

Quantitative structure-activity relationships of cyclin-dependent kinase 1 inhibitors

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2007
A new approach for quantitative structure-activity relationships based on MNA descriptors, fuzzy gradation method and self-consistent regression has been proposed. This approach has been realized in the computer program GUSAR (General Unrestricted Structure Activity Relationships). Our method has been validated on CDK1 inhibitors.
A V, Zakharov, A A, Lagunin, D A, Filimonov, V V, Poroĭkov   +3 more
openaire   +2 more sources

Pharmacological Cyclin-Dependent Kinase Inhibitors as HIV-1 Antiviral Therapeutics

Current HIV Research, 2003
Human immunodeficiency virus type 1 (HIV-1) can infect quiescent cells; however, viral production is restricted to actively proliferating cells. Recent evidence has indicated that HIV-1 viral proteins, Vpr and Tat, perturb the cell cycle to optimize HIV-1 replication. Vpr arrests the cell cycle at G2 by inactivating the cyclin B/cdk1 complex.
Cynthia, de la Fuente, Anil, Maddukuri, Kylene, Kehn, Shanese Y, Baylor, Longwen, Deng, Anne, Pumfery, Fatah, Kashanchi   +6 more
openaire   +2 more sources

Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma

Biochemical Pharmacology, 2021
The pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes with diagnostic and prognostic meaning and to identify potential therapeutic agents for HCC treatment ...
Shuangshuang, Yin, Shenshen, Yang, Yanming, Luo, Jia, Lu, Gaoyong, Hu, Kailong, Wang, Yingying, Shao, Shiyue, Zhou, Sangho, Koo, Yuling, Qiu, Tao, Wang, Haiyang, Yu   +11 more
openaire   +2 more sources

Regulation of AMP‐Activated Protein Kinase by Cyclin‐Dependent Kinase 1 in Mitosis

The FASEB Journal, 2016
In this study, we found that phosphorylation of both of the alpha subunits of AMP‐Activated Protein Kinase (AMPKα) are intensified in mitotically arrested cells. Further study showed that this was not due to phosphorylation at Thr172.
Seth D Stauffer, Xingcheng Chen, Yuanhong Chen, Jixin Dong   +3 more
openaire   +1 more source

Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle

Current Opinion in Cell Biology, 2000
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in ...
S V, Ekholm, S I, Reed
openaire   +2 more sources

Regulation of G₁ cyclin‐dependent kinases in liver regeneration

Journal of Gastroenterology and Hepatology, 1998
The liver serves as a suitable model for studying tissue regeneration. Although various growth factors have been implicated in the promotion of this process, their precise role in liver regeneration remains to be elucidated. Whatever the extracellular signals may be, they all converge on cell cycle regulators in the nucleus, where the sequential ...
Masafumi, Menjo, Kyoji, Ikeda, Makoto, Nakanishi   +2 more
openaire   +3 more sources

Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex

NeuroReport, 2008
Che-1 is a nuclear protein involved in the regulation of gene transcription and cell proliferation. It has also been shown to localize to the cytoplasm of postmitotic neuronal cells, where it is able to interact with the microtubule-associated protein tau.
Buontempo S, Barbato C, Bruno T, Corbi N, Ciotti MT, Floridi A, Fanciulli M, Passananti C   +7 more
openaire   +4 more sources