Results 261 to 270 of about 109,030,997 (289)
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Expression and Prognostic Role of Cyclin-Dependent Kinase 1 (cdc2) in Hepatocellular Carcinoma
Oncology, 2000The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high α-fetoprotein level, large size, high Ki-67 labeling index and poor ...
Y, Ito +5 more
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Structural Bioinformatics Approach of Cyclin‐Dependent Kinases 1 and 3 Complexed with Inhibitors
Molecular Informatics, 2011AbstractThe cyclin‐dependent kinases or CDKs participate in the regulation of both the cell progression cycle and the RNA polymerase‐II transcription cycle. In several human tumours deregulation of CDK‐related mechanisms have been detected, e.g., overexpression of cyclins or deletion of genes encoding for CKIs.
Lucas A, Saraiva +3 more
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Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1
Biochemical and Biophysical Research Communications, 2008DNA methyltransferase 1 (Dnmt1) is an enzyme that recognizes and methylates hemimethylated CpG after DNA replication to maintain methylation patterns. Although the N-terminal region of Dnmt1 is known to interact with various proteins, such as methyl-CpG-binding protein 2 (MeCP2), the associations of protein kinases with this region have not been ...
Isamu, Kameshita +7 more
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Reovirus Oncolysis- Role of cyclin-dependent kinase inhibitor 1
Cancer Cell & Microenvironment, 2015New therapeutic interventions are essential for improved cancer management. Over the past decade, reovirus, a naturally-occurring oncolytic double-stranded RNA virus harboring an intrinsic preference to destroy mutant KRAS driven tumors, has shown novel promissory potential.
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Genes to Cells, 2007
Disabled‐1 (Dab1) is an adaptor protein mediating Reelin signaling in neuronal migration during brain development. Cyclin‐dependent kinase 5 (Cdk5)–p35 is a proline‐directed Ser/Thr kinase also involved in neuronal migration. The interaction between Dab1 and Cdk5 is in need of investigation. Dab1 was phosphorylated at Ser400 and Ser491 by Cdk5 in vivo.
Yutaka, Sato +9 more
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Disabled‐1 (Dab1) is an adaptor protein mediating Reelin signaling in neuronal migration during brain development. Cyclin‐dependent kinase 5 (Cdk5)–p35 is a proline‐directed Ser/Thr kinase also involved in neuronal migration. The interaction between Dab1 and Cdk5 is in need of investigation. Dab1 was phosphorylated at Ser400 and Ser491 by Cdk5 in vivo.
Yutaka, Sato +9 more
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ik3‐1/Cables is a substrate for cyclin‐dependent kinase 3 (cdk 3)
European Journal of Biochemistry, 2001p70ik3‐1 (a 70‐kDa protein) contains a cyclin box, and binds to p35cdk3in vivo and in vitro[Matsuoka, M., Matsuura, Y., Semba, K. & Nishimoto, I. (2000) Biochem. Biophys. Res. Commun.273, 442–447]. In spite of its structural similarity to cyclins, p70ik3‐1 does not activate cyclin‐dependent kinase 3 (cdk3)‐mediated phosphorylation of pRb, histone ...
T, Yamochi +7 more
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Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review
International Journal of Molecular Sciences, 2021Izabela Gutowska +2 more
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Cyclin-Dependent Kinase 1: Expression pattern and therapeutic implications
2022Sofi, Shazia, Mir, Manzoor Ahmad
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A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)
Expert Opinion on Therapeutic Patents, 2023Vladimír Kryštof +2 more
exaly