Results 281 to 290 of about 805,965 (369)

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

A Nestin–Cyclin-Dependent Kinase 5–Dynamin-Related Protein 1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift [PDF]

, 2018
Jiancheng Wang, Yinong Huang, Jianye Cai, Qiong Ke, Jiaqi Xiao, Weijun Huang, Hongyu Li, Yuan Qiu, Yi Wang, Bin Zhang, Hao‐Xiang Wu, Yanan Zhang, Xin Sui, Adham Sameer A. Bardeesi, Andy Peng Xiang   +14 more
openalex   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception [PDF]

, 2018
Bradford E. Hall, Michaela Prochazkova, Matthew R. Sapio, Paul D. Minetos, Natalya Kurochkina, Binukumar BK, Niranjana D. Amin, Anita Terse, John Joseph, Stephen J. Raithel, Andrew J. Mannes, Harish C. Pant, Man‐Kyo Chung, Michael J. Iadarola, Ashok B. Kulkarni   +14 more
openalex   +1 more source

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity. [PDF]

Cell Death Dis, 2019
Yin L, Zeng Y, Xiao Y, Chen Y, Shen H, Dong J.   +5 more
europepmc   +1 more source

Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives

VIEW, EarlyView.
In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J. Saladin, Youlan Lei, Weibo Cai, Lei Kang   +6 more
wiley   +1 more source

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins

, 2011
Vasco Liberal, Hanna-Stina Martinsson-Ahlzén, Jennifer Liberal, Charles Spruck, Martin Widschwendter, Clare H. McGowan, Steven I. Reed   +6 more
openalex   +1 more source

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion [PDF]

, 2019
Haitao Zhang, Auburn Ramsey, Yitong Xiao, Uddhab Karki, Jennifer Y. Xie, Jianfeng Xu, Thomas J. Kelly, Shoichiro Ono, Guo-Lei Zhou   +8 more
openalex   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines

, 2011
Lan Xiao, Yuhong Cui, Jaladanki N. Rao, Tongtong Zou, Lan Liu, Alexis D. Smith, Douglas J. Turner, Myriam Gorospe, Jian‐Ying Wang   +8 more
openalex   +1 more source