Results 291 to 300 of about 805,965 (369)

Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy. [PDF]

Cell Signal, 2018
Wang Z, Chen X, Zhong MZ, Yang S, Zhou J, Klinkebiel DL, Karpf AR, Chen Y, Dong J.   +8 more
europepmc   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay. [PDF]

J Vis Exp, 2018
Cui H, Loftus KM, Noell CR, Solmaz SR.
europepmc   +1 more source

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source

A sejtek osztódásának aktiválásában és szabályozásában szerepet játszó fehérjék lucernában [PDF]

, 2008
Miskolczi Pál
core  

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone. [PDF]

J Biol Chem, 2018
Takahashi A, Mulati M, Saito M, Numata H, Kobayashi Y, Ochi H, Sato S, Kaldis P, Okawa A, Inose H.   +9 more
europepmc   +1 more source

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

Pumilio directs deadenylation-associated translational repression of the cyclin-dependent kinase 1 activator RGC-32. [PDF]

Nucleic Acids Res, 2018
Brocard M, Khasnis S, Wood CD, Shannon-Lowe C, West MJ.   +4 more
europepmc   +1 more source

Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging

Aging Cell, EarlyView.
Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer, E. Kinloch, P. J. Lucassen, E. Salta, C. P. Fitzsimons   +4 more
wiley   +1 more source