Results 1 to 10 of about 116 (89)

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source

Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]

PLoS ONE, 2013
Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak, Federico Rojas, Cecilia D'Alessio, Salomé C Vilchez Larrea, Vanina Rodriguez, Pablo D Ghiringhelli, María T Téllez-Iñón   +6 more
doaj   +1 more source

TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Cell Death and Disease, 2023
The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar, Pradip Sen   +4 more
doaj   +1 more source

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

MedComm, 2022
Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang, Wei Wang, Jia‐Xin Qin, Zhen‐Duo Shi, Lin Hao, Yu‐Yang Ma, Hao Xu, Zhuo‐Xun Wu, Deng Pan, Zhe‐Sheng Chen, Cong‐Hui Han   +10 more
doaj   +1 more source

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

Scientific Reports, 2021
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
Simon Uzor, Sean R. Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A. Alqasem, Claire M. Perks, Ian D. Wilson, Sebastian Oltean, Michael R. Ladomery   +11 more
doaj   +1 more source

Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core

Molecules, 2022
The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases.
Mihaela-Liliana Ţînţaş, Ludovic Peauger, Florent Alix, Cyril Papamicaël, Thierry Besson, Jana Sopková-de Oliveira Santos, Vincent Gembus, Vincent Levacher   +7 more
doaj   +1 more source

Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1

Neoplasia: An International Journal for Oncology Research, 2001
Bcl-2 is a critical suppressor of apoptosis that is overproduced in many types of cancer. Phosphorylation of the Bcl-2 protein is induced on serine residues in tumor cells arrested by microtubule-targeting drugs (paclitaxel, vincristine, nocodazole) and ...
Nuzhat Pathan, Christine Aime-sempe, Shinichi Kitada, Subrata Haldar, John C. Reed   +4 more
doaj   +1 more source

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

PLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn, John M Asara, Reuben J Shaw   +2 more
doaj   +1 more source

Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway

Frontiers in Genetics, 2020
C-terminally truncated hepatitis B virus (HBV) X (ctHBx) infection and exposure to microcystins-LR (MC-LR) can lead to human hepatitis and liver cancer, but the mechanism associated with their synergistically effects not been fully elucidated. The ctHBx (
Chanchan Xiao, Fanbiao Mei, Guanhua Ren, Long Long, Maojian Chen, Xiang Fang, Jilin Li, Kezhi Li, Yanping Tang, Tianren Huang, Wei Deng   +10 more
doaj   +1 more source

Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs

Marine Drugs, 2010
For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins.
Alicia Marquardt, Samuel Abernathy, Jose R. Escalona, Stephen A. Stricker   +3 more
doaj   +1 more source