Results 1 to 10 of about 3,589,787 (212)

Activation of type-1 protein phosphatase by cdc2 kinase [PDF]

FEBS Letters, 1992
Purified cdc2 or cdc2 obtained from HeLa cells in association with p131sucl activate inactive type‐1 protein phosphatase (PP1) (catalytic subunit · inhibitor‐2 complex, purified from skeletal muscle). Likewise in the case of PP1 activation by FA/GSK3, activation by cdc2 is accompanied by phosphorylation of inhibitor‐2 (I2) and free I2 can be ...
E Villa-Moruzzi
exaly   +3 more sources

A Novel cdc2‐Related Protein Kinase Expressed in the Nervous System [PDF]

Journal of Neurochemistry, 1997
Abstract: We report the cloning and characterization of a cDNA encoding a cdc2‐related protein kinase, named PFTAIRE, that is expressed primarily in the postnatal and adult nervous system. We have demonstrated by in situ hybridization and indirect immunofluorescence that several populations of terminally differentiated neurons and some neuroglia ...
Paul R Albert, Jean-Pierre Julien, J P Julien   +2 more
exaly   +3 more sources

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source

Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]

PLoS ONE, 2013
Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak, Federico Rojas, Cecilia D'Alessio, Salomé C Vilchez Larrea, Vanina Rodriguez, Pablo D Ghiringhelli, María T Téllez-Iñón   +6 more
doaj   +1 more source

A family of human cdc2‐related protein kinases. [PDF]

The EMBO Journal, 1992
The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2.
M, Meyerson, G H, Enders, C L, Wu, L K, Su, C, Gorka, C, Nelson, E, Harlow, L H, Tsai   +7 more
openaire   +2 more sources

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. [PDF]

Proceedings of the National Academy of Sciences, 1992
Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 177-186 and Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C.
M R, Hellmich, H C, Pant, E, Wada, J F, Battey   +3 more
openaire   +2 more sources

TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Cell Death and Disease, 2023
The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response.
Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar, Pradip Sen   +4 more
doaj   +1 more source

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

MedComm, 2022
Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang, Wei Wang, Jia‐Xin Qin, Zhen‐Duo Shi, Lin Hao, Yu‐Yang Ma, Hao Xu, Zhuo‐Xun Wu, Deng Pan, Zhe‐Sheng Chen, Cong‐Hui Han   +10 more
doaj   +1 more source

The Protein-tyrosine Kinase Lck Associates with and Is Phosphorylated by Cdc2 [PDF]

Journal of Biological Chemistry, 1996
The protein-tyrosine kinase Lck is essential for signaling through the T-cell antigen receptor. Treatment of T-cells with a variety of extracellular stimuli increases the phosphorylation of Lck on serine residues. This results in shifts in the apparent molecular weight of Lck to forms that exhibit reduced electrophoretic mobility on SDS-polyacrylamide ...
N I, Pathan, R L, Geahlen, M L, Harrison
openaire   +2 more sources

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

Scientific Reports, 2021
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
Simon Uzor, Sean R. Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A. Alqasem, Claire M. Perks, Ian D. Wilson, Sebastian Oltean, Michael R. Ladomery   +11 more
doaj   +1 more source