Results 31 to 40 of about 4,659,967 (205)

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source

Regulation of Chk1

Cell Division, 2009
Chk1 is a serine/threonine protein kinase that is the effector of the G2 DNA damage checkpoint. Chk1 homologs have a highly conserved N-terminal kinase domain, and a less conserved C-terminal regulatory domain of ~200 residues.
Calonge Teresa M, Tapia-Alveal Claudia, O'Connell Matthew J   +2 more
doaj   +1 more source

Zinc regulates meiotic resumption in porcine oocytes via a protein kinase C-related pathway. [PDF]

PLoS ONE, 2014
Zinc is an extremely important trace element that plays important roles in several biological processes. However, the function of zinc in meiotic division of porcine oocytes is unknown.
Ming-Hui Zhao, Jung-Woo Kwon, Shuang Liang, Seon-Hyang Kim, Ying-Hua Li, Jeong-Su Oh, Nam-Hyung Kim, Xiang-Shun Cui   +7 more
doaj   +1 more source

Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum. [PDF]

PLoS Pathogens, 2015
Eukaryotic cell cycle involves a number of protein kinases important for the onset and progression through mitosis, most of which are well characterized in the budding and fission yeasts and conserved in other fungi.
Huiquan Liu, Shijie Zhang, Jiwen Ma, Yafeng Dai, Chaohui Li, Xueliang Lyu, Chenfang Wang, Jin-Rong Xu   +7 more
doaj   +1 more source

Mitotic Regulation of Protein 4.1R Involves Phosphorylation by cdc2 Kinase [PDF]

Molecular Biology of the Cell, 2005
The nonerythrocyte isoform of the cytoskeletal protein 4.1R (4.1R) is associated with morphologically dynamic structures during cell division and has been implicated in mitotic spindle function. In this study, we define important 4.1R isoforms expressed in interphase and mitotic cells by RT-PCR and mini-cDNA library construction. Moreover, we show that
Shu-Ching, Huang, Eva S, Liu, Siu-Hong, Chan, Indira D, Munagala, Heidi T, Cho, Ramasamy, Jagadeeswaran, Edward J, Benz   +6 more
openaire   +2 more sources

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

The regulation of tau phosphorylation by PCTAIRE 3: Implications for the pathogenesis of Alzheimer's disease

Neurobiology of Disease, 2006
In the course of Alzheimer's disease, phosphorylated tau aggregates to form paired helical filaments, highly ordered filamentous structures that accumulate within neurons and contribute to the formation of neurofibrillary tangles. This study examines the
A.Z. Herskovits, P. Davies
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Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe

Cell Division, 2020
The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator
John P. Alao, Per Sunnerhagen
doaj   +1 more source

Comparative analysis of two murine CDC25B isoforms [PDF]

Archives of Biological Sciences, 2017
CDC25B phosphatase plays a pivotal role in the cell cycle process by dephosphorylating and activating the CDC2 kinase of maturation-promoting factor (MPF). In mice, two transcripts of Cdc25B are generated by the alternative splicing of one gene.
Kang Min Kook, Bang Aera, Choi Ok Hwa, Han Seung Jin   +3 more
doaj   +1 more source

Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer’s Disease: A Computational Study

Marine Drugs, 2018
Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing.
Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martinez   +3 more
doaj   +1 more source