Results 31 to 40 of about 3,589,787 (212)

Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum. [PDF]

PLoS Pathogens, 2015
Eukaryotic cell cycle involves a number of protein kinases important for the onset and progression through mitosis, most of which are well characterized in the budding and fission yeasts and conserved in other fungi.
Huiquan Liu, Shijie Zhang, Jiwen Ma, Yafeng Dai, Chaohui Li, Xueliang Lyu, Chenfang Wang, Jin-Rong Xu   +7 more
doaj   +1 more source

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

The regulation of tau phosphorylation by PCTAIRE 3: Implications for the pathogenesis of Alzheimer's disease

Neurobiology of Disease, 2006
In the course of Alzheimer's disease, phosphorylated tau aggregates to form paired helical filaments, highly ordered filamentous structures that accumulate within neurons and contribute to the formation of neurofibrillary tangles. This study examines the
A.Z. Herskovits, P. Davies
doaj   +1 more source

Identification of Inhibitors of the Leishmania cdc2‐Related Protein Kinase CRK3 [PDF]

ChemMedChem, 2011
AbstractNew drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high‐throughput screen of a focussed kinase set of ∼3400 compounds to identify potent and parasite‐selective inhibitors of an enzymatic Leishmania CRK3–cyclin 6 complex.
Cleghorn, Laura A. T., Woodland, Andrew, Collie, Iain T., Torrie, Leah S., Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G., Mottram, Jeremy C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.   +12 more
openaire   +3 more sources

Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe

Cell Division, 2020
The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator
John P. Alao, Per Sunnerhagen
doaj   +1 more source

Comparative analysis of two murine CDC25B isoforms [PDF]

Archives of Biological Sciences, 2017
CDC25B phosphatase plays a pivotal role in the cell cycle process by dephosphorylating and activating the CDC2 kinase of maturation-promoting factor (MPF). In mice, two transcripts of Cdc25B are generated by the alternative splicing of one gene.
Kang Min Kook, Bang Aera, Choi Ok Hwa, Han Seung Jin   +3 more
doaj   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680)   +17 more
core   +1 more source

Mitotic Regulation of Protein 4.1R Involves Phosphorylation by cdc2 Kinase [PDF]

Molecular Biology of the Cell, 2005
The nonerythrocyte isoform of the cytoskeletal protein 4.1R (4.1R) is associated with morphologically dynamic structures during cell division and has been implicated in mitotic spindle function. In this study, we define important 4.1R isoforms expressed in interphase and mitotic cells by RT-PCR and mini-cDNA library construction. Moreover, we show that
Shu-Ching, Huang, Eva S, Liu, Siu-Hong, Chan, Indira D, Munagala, Heidi T, Cho, Ramasamy, Jagadeeswaran, Edward J, Benz   +6 more
openaire   +2 more sources

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]

, 2012
The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Engels, Kristin K., Marhofer, Richard J., Bender, Frank, Mottram, Jeremy C., Gassel, Michael, Selzer, Paul M., Fernandez, Maria L. Suarez   +6 more
core   +1 more source

Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer’s Disease: A Computational Study

Marine Drugs, 2018
Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing.
Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martinez   +3 more
doaj   +1 more source