High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. [PDF]
PLoS Neglected Tropical Diseases, 2011 Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active ...
Roderick G Walker +9 more
doaj +8 more sources
Regulation of the Vertebrate Cell Cycle by the cdc2 Protein Kinase
Cold Spring Harbor Symposia on Quantitative Biology, 1988 A homolog of the cdc2/CDC28 protein kinase of yeast is found in all vertebrate species that have been investigated. Human cdc2 exists as a complex with a 13-kD protein that is homologous to the suc1 gene product of fission yeast. In both human and fission yeast cells, the protein kinase also exists in a complex with a 62-kD polypeptide that has not ...
G, Draetta +3 more
openaire +3 more sources
Generating and Expanding Conventional Type 1 Dendritic Cells [PDF]
European Journal of Immunology, Volume 56, Issue 10, October 2026.Conventional type 1 dendritic cells (cDC1s) are difficult to obtain in sufficient numbers. This Review compares strategies based on progenitor differentiation, cell programming, or expansion in tissues, and shows how differences in cell identity, population composition, function, and yield should guide platform selection.
Sukriti Sharma +2 more
wiley +2 more sources
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. [PDF]
Proceedings of the National Academy of Sciences, 1994 Members of the cell division cycle 2 (CDC2) family of kinases play a pivotal role in the regulation of the eukaryotic cell cycle. In this communication, we report the isolation of a cDNA that encodes a CDC2-related human protein kinase temporarily designated PITALRE for the characteristic Pro-Ile-Thr-Ala-Leu-Arg-Glu motif.
GRANA X +7 more
openaire +7 more sources
Casticin From Sanse Powder‐ In Vitro Release Medium Inhibits FAK/PI3K/AKT Phosphorylation Reducing Synovial Senescence and Alleviates Inflammation in Knee Osteoarthritis [PDF]
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACT Sanse Powder (SSP) has been shown to be effective in the clinical treatment of knee osteoarthritis (KOA), although its active components and underlying mechanisms remain unclear. In this study, we collected the in vitro release medium of SSP (SSP‐IVRM) using an in vitro release test and evaluated its pharmacological effects in a KOA rat model.
Jiangyu Liu +10 more
wiley +2 more sources
An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development [PDF]
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar +3 more
wiley +2 more sources
Quercetin and Cardiovascular Health: An Evidence‐Based Review of Risk Factors and Treatments [PDF]
Food Science &Nutrition, Volume 14, Issue 11, November 2026.Quercetin is a naturally occurring polyphenolic phytochemical distributed in fruits and vegetables. Quercetin, as a flavonoid, showed significant antioxidant capabilities and potential therapeutic effects on CVD risk factors. Quercetin reduces cardiac hypertrophy and apoptosis in cardiomyocytes by modulating critical signaling pathways.
Mohammad Reza Khazdair +2 more
wiley +2 more sources
Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1 [PDF]
The FEBS Journal, Volume 293, Issue 21, Page 6525-6551, November 2026.In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández +4 more
wiley +2 more sources
The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle
Journal of Cell Science, 1989 ABSTRACT Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G2 to M phase in eukaryotic cells. We shall review our knowledge of the mechanisms which coordinate activation of the kinase with cell cycle-specific events in mammalian cells.
G, Draetta, D, Beach
openaire +3 more sources
Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]
, 1995 Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J. +2 more
core +4 more sources