Results 11 to 20 of about 3,589,787 (212)
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. [PDF]
PLoS Neglected Tropical Diseases, 2011 Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active ...
Roderick G Walker +9 more
doaj +8 more sources
An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development [PDF]
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar +3 more
wiley +2 more sources
Regulation of the Vertebrate Cell Cycle by the cdc2 Protein Kinase
Cold Spring Harbor Symposia on Quantitative Biology, 1988 A homolog of the cdc2/CDC28 protein kinase of yeast is found in all vertebrate species that have been investigated. Human cdc2 exists as a complex with a 13-kD protein that is homologous to the suc1 gene product of fission yeast. In both human and fission yeast cells, the protein kinase also exists in a complex with a 62-kD polypeptide that has not ...
G, Draetta +3 more
openaire +3 more sources
Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]
, 1995 Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J. +2 more
core +4 more sources
The design of peptide-based substrates for the cdc2 protein kinase [PDF]
Biochemical Journal, 1995 The substrate sequence specificity of the cdc2 protein kinase from Pisaster ochraceus has been evaluated. The peptide, Ac-Ser-Pro-Gly-Arg-Arg-Arg-Arg-Lys-amide, serves as an efficient cdc2 kinase substrate with a Km of 1.50 +/- 0.04 microM and a Vmax. of 12.00 +/- 0.18 mumol/min per mg.
J, Srinivasan +4 more
openaire +2 more sources
Learning Induces a CDC2-Related Protein Kinase, KKIAMRE [PDF]
The Journal of Neuroscience, 1999 To elucidate molecular mechanisms in learning and memory, we analyzed expression of mRNAs in brains of rabbits undergoing eyeblink conditioning. Infusion of the transcription inhibitor actinomycin D into the cerebellar interpositus nucleus reversibly blocked learning but not performance of the conditioned response.
H, Gomi +5 more
openaire +2 more sources
The Retinoblastoma Protein Physically Associates with the Human cdc2 Kinase [PDF]
Molecular and Cellular Biology, 1992 The protein product (pRB) of the retinoblastoma susceptibility gene functions as a negative regulator of cell proliferation, and its activity appears to be modulated by phosphorylation. Using a new panel of anti-human pRB monoclonal antibodies, we have investigated the biochemical properties of this protein. These antibodies have allowed us to detect a
Q J, Hu +3 more
openaire +2 more sources
Molecules, 2022 The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases.
Mihaela-Liliana Ţînţaş +7 more
doaj +1 more source
Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1
Neoplasia: An International Journal for Oncology Research, 2001 Bcl-2 is a critical suppressor of apoptosis that is overproduced in many types of cancer. Phosphorylation of the Bcl-2 protein is induced on serine residues in tumor cells arrested by microtubule-targeting drugs (paclitaxel, vincristine, nocodazole) and ...
Nuzhat Pathan +4 more
doaj +1 more source
Raptor is phosphorylated by cdc2 during mitosis. [PDF]
PLoS ONE, 2010 The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn +2 more
doaj +1 more source