Results 41 to 50 of about 4,659,967 (205)

Bacillus subtilis KLBMPGC81 suppresses appressorium-mediated plant infection by altering the cell wall integrity signaling pathway and multiple cell biological processes in Magnaporthe oryzae

Frontiers in Cellular and Infection Microbiology, 2022
Magnaporthe oryzae is one of the most destructive crop pathogens in the world, causing huge losses in rice harvest every year. Bacillus subtilis is a potential biocontrol agent that has been explored in many crop systems because it is a potent producer ...
Lianwei Li, Yanru Li, Kailun Lu, Rangrang Chen, Jihong Jiang   +4 more
doaj   +1 more source

Identification of Inhibitors of the Leishmania cdc2‐Related Protein Kinase CRK3 [PDF]

ChemMedChem, 2011
AbstractNew drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work involved a high‐throughput screen of a focussed kinase set of ∼3400 compounds to identify potent and parasite‐selective inhibitors of an enzymatic Leishmania CRK3–cyclin 6 complex.
Cleghorn, Laura A. T., Woodland, Andrew, Collie, Iain T., Torrie, Leah S., Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G., Mottram, Jeremy C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.   +12 more
openaire   +3 more sources

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin

Molecules, 2017
HER2/neu positive breast tumors predict a high mortality and comprise 25%–30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2 ...
Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi   +7 more
doaj   +1 more source

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents

Marine Drugs, 2017
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery.
Laura Llorach-Pares, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Conxita Avila   +3 more
doaj   +1 more source

In Silico Characterization of a Cyclin Dependent Kinase -A (CDKA) and its Coding Gene in some Oryza Species

مجلة بغداد للعلوم, 2020
Rice (Oryza sativa) is a fundamental food for the majority of world population. Cyclin Dependent Kinase -A (CDKA) accelerates transition through different stages of cell cycle and contributes in gametes formation.
Ahmed Sayed Fouad, Sanad M AlSobeai
doaj   +1 more source

Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. [PDF]

PLoS ONE, 2017
Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes. Mice lacking CK1δ have a perinatal lethal phenotype and typically weigh 30% less than their wild type littermates.
Yoshimi Endo Greer, Bo Gao, Yingzi Yang, Andre Nussenzweig, Jeffrey S Rubin   +4 more
doaj   +1 more source

Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity

Frontiers in Physiology, 2021
Increasing energy expenditure by promoting “browning” in adipose tissues is a promising strategy to prevent obesity and associated diabetes. To uncover potential targets of cold exposure, which induces energy expenditure, we performed phosphoproteomics ...
Zhenguo Wang, Zhenguo Wang, Xiaojing Gao, Xiaojing Gao, Qingrun Li, Hongwen Zhu, Xiangjie Zhao, Minerva Garcia-Barrio, Jifeng Zhang, Yanhong Guo, Y. Eugene Chen, Rong Zeng, Rong Zeng, Jia-Rui Wu, Jia-Rui Wu, Lin Chang   +15 more
doaj   +1 more source

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]

, 2012
The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Engels, Kristin K., Marhofer, Richard J., Bender, Frank, Mottram, Jeremy C., Gassel, Michael, Selzer, Paul M., Fernandez, Maria L. Suarez   +6 more
core   +1 more source

Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Signal Transduction and Targeted Therapy, 2023
The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12), catalyzing spliceosome molecular machinery, and modulating the ...
Mengqiu Song, Luping Pang, Mengmeng Zhang, Yingzi Qu, Kyle Vaughn Laster, Zigang Dong   +5 more
doaj   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source