Results 61 to 70 of about 4,659,967 (205)

c‐MET Inhibition Is Accompanied by PD‐L1 Upregulation and Immunosuppression‐Related Tumor Microenvironment Changes in Esophageal Squamous Cell Carcinoma, With Enhanced Antitumor Activity in Combination With Anti‐PD‐1 Therapy

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background c‐MET is implicated in ESCC progression, but whether c‐MET inhibition reshapes immune checkpoint expression and the tumor immune microenvironment remains unclear. Methods ESCC cell lines were treated with Tepotinib, and c‐MET and PD‐L1 expression were examined by Western blotting and immunofluorescence.
Chuan Song, Zhe Xia, Hu Wang, Xinyu Wang, Jing Li, Binbin Wang, Chen Feng, Bo Xie   +7 more
wiley   +1 more source

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation [PDF]

, 1997
Cytolethal distending toxins (CDT) constitute an emerging heterogeneous family of bacterial toxins whose common biological property is to inhibit the proliferation of cells in culture by blocking their cycle at G2/M phase.
Pérès, Sylvie Yvonne, Oswald, E., Comayras, C., de Rycke, Jean, Oswald, Eric, Comayras, Chrystel, Tasca, Christian, Rycke, Jean de, Ducommun, Bernard, Pérès, S.Y., Ducommun, B.   +10 more
core  

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.

PLoS ONE, 2010
BackgroundHistone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been well understood and no clear mechanism of resistance has been elucidated to explain ...
William Brazelle, Jenny M Kreahling, Jennifer Gemmer, Yihong Ma, W Douglas Cress, Eric Haura, Soner Altiok   +6 more
doaj   +1 more source

Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells. [PDF]

PLoS ONE, 2016
Nicotine is, to a large extent, responsible for smoking-mediated renal dysfunction. This study investigated nicotine's effects on renal tubular epithelial cell apoptosis in vitro and it explored the mechanisms underlying its effects.Human proximal ...
Chang Seong Kim, Joon Seok Choi, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, JongUn Lee, Soo Wan Kim   +6 more
doaj   +1 more source

Regulatory T Cells in Health and Disease

MedComm, Volume 7, Issue 11, November 2026.
Regulatory T cells (Tregs) arise through distinct developmental pathways and adapt to specialized tissue niches to maintain immune tolerance, barrier integrity, and metabolic homeostasis. In disease, Tregs undergo context‐dependent changes, ranging from functional insufficiency and lineage instability in autoimmune, inflammatory, cardiovascular, and ...
Mingyi Li, Si Zhang, Tangchun Wu, Tingting Tang, Xiang Cheng   +4 more
wiley   +1 more source

Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes. [PDF]

PLoS ONE, 2013
The development of adipocytes from their progenitor cells requires the action of growth factors signaling to transcription factors to induce the expression of adipogenic proteins leading to the accumulation of lipid droplets, induction of glucose ...
Pengfei Li, Gay Carter, Jacqueline Romero, Kathryn M Gower, James Watson, Niketa A Patel, Denise R Cooper   +6 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]

, 1998
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M., Erich A. Nigg, Stierhof, Y. D., Mayor, T., Y. D. Stierhof (7653686), Tanaka, K., Nigg, E. A., Meraldi, P., Thibault Mayor, A. M. Fry (7651490), E. A. Nigg (7651493), Kayoko Tanaka, Andrew M. Fry, P. Meraldi (7653683), K. Tanaka (1500880), Patrick Meraldi, York-Dieter Stierhof, T. Mayor (7653680), Meraldi P, Nigg EA, Fry AM, Tanaka K, Mayor T, Stierhof YD   +23 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins

Journal of Biological Chemistry, 1993
Tau protein kinase II purified from a bovine brain tau protein fraction (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T., and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901) was shown to have a similar substrate specificity to cdc2 kinase in that both phosphorylate neurofilament (NF) proteins. Tau protein
S, Hisanaga, K, Ishiguro, T, Uchida, E, Okumura, T, Okano, T, Kishimoto   +5 more
openaire   +2 more sources