Results 81 to 90 of about 4,659,967 (205)

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Parasites & Vectors, 2014
Background In search of new antiparasitic agents for overcoming the limitations of current leishmaniasis chemotherapy, we have previously shown that 6-bromoindirubin-3'-oxime (6BIO) and several other 6-substituted analogues of indirubin, a naturally ...
Antonia Efstathiou, Nicolas Gaboriaud-Kolar, Despina Smirlis, Vassilios Myrianthopoulos, Konstantina Vougogiannopoulou, Alexandros Alexandratos, Marina Kritsanida, Emmanuel Mikros, Ketty Soteriadou, Alexios-Leandros Skaltsounis   +9 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Physiological, genetical changes and cdc2 gene expression for osmotic stressed Vicia faba reveal the alleviation effect of gamma radiation and putrescine

Caryologia
Climate change caused increasing in soil salinity worldwide. Therefore, it is critical to enhance the capability of plant to tolerate salinity stress. For this goal, putrescine and irradiation by gamma radiation were used to improve the salt tolerance of
Shaimaa S. Sobieh, Noha Eid Eliwa
doaj   +1 more source

Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.

PLoS Pathogens, 2009
The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
Sofia Hamirally, Jeremy P Kamil, Yasmine M Ndassa-Colday, Alison J Lin, Wan Jin Jahng, Moon-Chang Baek, Sarah Noton, Laurie A Silva, Martha Simpson-Holley, David M Knipe, David E Golan, Jarrod A Marto, Donald M Coen   +12 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, Volume 13, Issue 52, 18 September 2026.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice

Frontiers in Behavioral Neuroscience, 2010
Cyclin-dependent kinase-like 2 (Cdkl2) is a cdc2-related serine/threonine protein kinase that is postnatally expressed in various brain regions, including the cerebral cortex, entorhinal cortex, hippocampus, amygdala, and dorsal thalamus.
Hiroshi Gomi, Hiroshi Gomi, Takayuki Sassa, Richard F Thomson, Shigeyoshi Itohara   +4 more
doaj   +1 more source

Investigation of CDC2-independent mitotic protein kinases

, 1997
Mitosis is a highly coordinated event which ensures the equal segregation of the cytoplasmic and genetic material into two daughter cells. A key regulatory process in ensuring the temporal fidelity of mitosis involves reversible protein phosphorylation
Gowdy, Patrick Michael
core   +1 more source

Role of C5b-9 and RGC-32 in Cancer

Frontiers in Immunology, 2019
The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the complement system culminates with the assembly of the C5b-9 terminal complement complex on cell ...
Sonia I. Vlaicu, Sonia I. Vlaicu, Alexandru Tatomir, Violeta Rus, Horea Rus   +4 more
doaj   +1 more source

Molecular cloning of a novel human cdc2/CDC28-like protein kinase

Journal of Biological Chemistry, 1991
A homology probing approach was utilized to isolate a new human protein kinase. Deoxyoligonucleotide probes recognizing a conserved subdomain in the COOH-terminal portion of protein kinases identified a cDNA clone encoding a putative kinase with predicted serine/threonine phosphorylation specificity.
K W, Johnson, K A, Smith
openaire   +2 more sources

CDK9 (PITALRE): a multifunctional cdc2-related kinase

, 1998
CDK9 is a cdc2-related kinase protein. Previously named PITALRE, this protein is a serine-threonine kinase involved in many physiological processes. Unlike most of the cdc2-like kinases, its activity is not cell cycle-regulated.
de Falco G., Giordano A.
core   +1 more source