Results 91 to 100 of about 4,659,967 (205)

p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase

Haematologica, 2003
BACKGROUND AND OBJECTIVES: The p210 bcr-abl fusion protein has a key role in the pathogenesis of chronic myeloid leukemia (CML). However, its influence on disease progression to blast crisis is marginal and mostly due to its effect of impairing the ...
G Brusa, M Benvenuti, L Mazzacurati, M Mancini, L Pattacini, G Martinelli, E Barbieri, JS Greenberger, M Baccarani, MA Santucci   +9 more
doaj  

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS ONE, 2019
The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a biological process previously thought to be highly conserved in all eukaryotes.
Leah S Torrie, Fabio Zuccotto, David A Robinson, David W Gray, Ian H Gilbert, Manu De Rycker   +5 more
doaj   +1 more source

Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei.

PLoS ONE, 2013
The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes trypanosomiasis in humans and animals. Both the life cycle and cell cycle of the parasite are complex. Trypanosomes have eleven cdc2-related kinases (CRKs) and ten cyclins,
Séverine Monnerat, Cristina I Almeida Costa, Andrea C Forkert, Corinna Benz, Alana Hamilton, Laurence Tetley, Richard Burchmore, Carlos Novo, Jeremy C Mottram, Tansy C Hammarton   +9 more
doaj   +1 more source

Phosphorylation of Replication Protein A: A Role for cdc2 Kinase in G1/S Regulation

Cold Spring Harbor Symposia on Quantitative Biology, 1991
Among the various phases of the cell cycle, we have concentrated on the regulation of the S phase. Our approach is to define biochemically the components of the DNA replication apparatus and then to analyze how the various components are regulated as cells enter, execute, and exit the S phase.
A, Dutta, S, Din, S J, Brill, B, Stillman   +3 more
openaire   +2 more sources

CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.

PLoS ONE, 2017
CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated
Wen-Shih Huang, Yi-Hung Kuo, Hsing-Chun Kuo, Meng-Chiao Hsieh, Cheng-Yi Huang, Ko-Chao Lee, Kam-Fai Lee, Chien-Heng Shen, Shui-Yi Tung, Chih-Chuan Teng   +9 more
doaj   +1 more source

Stress activated protein kinase pathway modulates homologous recombination in fission yeast.

PLoS ONE, 2012
Rad52 is a key player in homologous recombination (HR), a DNA repair pathway that is dedicated to double strand breaks repair and recovery of perturbed replication forks.
Angela Bellini, Pierre-Marie Girard, Sarah Lambert, Ludovic Tessier, Evelyne Sage, Stefania Francesconi   +5 more
doaj   +1 more source

Phosphorylation of amyloid-ß at the serine 26 residue by human cdc2 kinase

, 2001
The amyloid-β (Aβ) peptide has been implicated in the pathology of Alzheimer's disease (AD). Using an antisense peptide approach a novel interaction between Aβ and the human cdc2 kinase was identified.
Milton, N.G.N.
core  

Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34^cdc2 homologue

, 1993
To understand better growth regulation in the protozoan parasite, Entamoeba histolytica (Eh), a homologue of the cdc2 gene encoding the yeast cyclin-dependent protein kinase, p34cdc2, has been cloned and sequenced.
Samuelson, John, Lohia, Anuradha
core   +1 more source

Targeting the Cdc2‐like kinase 2 for overcoming platinum resistance in ovarian cancer

MedComm
Platinum resistance represents a major barrier to the survival of patients with ovarian cancer (OC). Cdc2‐like kinase 2 (CLK2) is a major protein kinase associated with oncogenic phenotype and development in some solid tumors. However, the exact role and
Yinan Jiang, Shuting Huang, Lan Zhang, Yun Zhou, Wei Zhang, Ting Wan, Haifeng Gu, Yi Ouyang, Xiaojing Zheng, Pingping Liu, Baoyue Pan, Huiling Xiang, Mingxiu Ju, Rongzhen Luo, Weihua Jia, Shenjiao Huang, Jundong Li, Min Zheng   +17 more
doaj   +1 more source

Pectenotoxin-2 from Marine Sponges: A Potential Anti-Cancer Agent—A Review

Marine Drugs, 2011
Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of ...
Wun-Jae Kim, Yung Hyun Choi, Gi-Young Kim   +2 more
doaj   +1 more source