Results 91 to 100 of about 3,589,787 (212)

Physiological, genetical changes and cdc2 gene expression for osmotic stressed Vicia faba reveal the alleviation effect of gamma radiation and putrescine

Caryologia
Climate change caused increasing in soil salinity worldwide. Therefore, it is critical to enhance the capability of plant to tolerate salinity stress. For this goal, putrescine and irradiation by gamma radiation were used to improve the salt tolerance of
Shaimaa S. Sobieh, Noha Eid Eliwa
doaj   +1 more source

Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.

PLoS Pathogens, 2009
The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress).
Sofia Hamirally, Jeremy P Kamil, Yasmine M Ndassa-Colday, Alison J Lin, Wan Jin Jahng, Moon-Chang Baek, Sarah Noton, Laurie A Silva, Martha Simpson-Holley, David M Knipe, David E Golan, Jarrod A Marto, Donald M Coen   +12 more
doaj   +1 more source

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice

Frontiers in Behavioral Neuroscience, 2010
Cyclin-dependent kinase-like 2 (Cdkl2) is a cdc2-related serine/threonine protein kinase that is postnatally expressed in various brain regions, including the cerebral cortex, entorhinal cortex, hippocampus, amygdala, and dorsal thalamus.
Hiroshi Gomi, Hiroshi Gomi, Takayuki Sassa, Richard F Thomson, Shigeyoshi Itohara   +4 more
doaj   +1 more source

Role of C5b-9 and RGC-32 in Cancer

Frontiers in Immunology, 2019
The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the complement system culminates with the assembly of the C5b-9 terminal complement complex on cell ...
Sonia I. Vlaicu, Sonia I. Vlaicu, Alexandru Tatomir, Violeta Rus, Horea Rus   +4 more
doaj   +1 more source

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]

, 2013
Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš, Stefan Zahler, Krystof, Vladimir, Strnad, Miroslav, Liebl, Johanna, Vollmar, Angelika M., Fürst, Robert, Vladimir Krystof, Robert Fürst, Sabine B Weitensteiner, Miroslav Strnad, Johanna Liebl, Havlíček, Libor, Tomáš Gucký, Weitensteiner, Sabine B., Zahler, Stefan, Libor Havlíček, Angelika M Vollmar   +17 more
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Phosphorylation of Replication Protein A: A Role for cdc2 Kinase in G1/S Regulation

Cold Spring Harbor Symposia on Quantitative Biology, 1991
Among the various phases of the cell cycle, we have concentrated on the regulation of the S phase. Our approach is to define biochemically the components of the DNA replication apparatus and then to analyze how the various components are regulated as cells enter, execute, and exit the S phase.
A, Dutta, S, Din, S J, Brill, B, Stillman   +3 more
openaire   +2 more sources

Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]

, 2010
The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core   +1 more source

Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase [PDF]

, 2007
The uptake and processing of nutrients is highly regulated. Cells adapt to changes of the availability of nutrients to provide a complete set of transporters and metabolizing enzymes for optimal use of the available nutrients.
Gander, Stefan
core   +1 more source

p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase

Haematologica, 2003
BACKGROUND AND OBJECTIVES: The p210 bcr-abl fusion protein has a key role in the pathogenesis of chronic myeloid leukemia (CML). However, its influence on disease progression to blast crisis is marginal and mostly due to its effect of impairing the ...
G Brusa, M Benvenuti, L Mazzacurati, M Mancini, L Pattacini, G Martinelli, E Barbieri, JS Greenberger, M Baccarani, MA Santucci   +9 more
doaj  

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS ONE, 2019
The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a biological process previously thought to be highly conserved in all eukaryotes.
Leah S Torrie, Fabio Zuccotto, David A Robinson, David W Gray, Ian H Gilbert, Manu De Rycker   +5 more
doaj   +1 more source