Results 101 to 110 of about 3,589,787 (212)
Molecular cloning of a novel human cdc2/CDC28-like protein kinase
Journal of Biological Chemistry, 1991 A homology probing approach was utilized to isolate a new human protein kinase. Deoxyoligonucleotide probes recognizing a conserved subdomain in the COOH-terminal portion of protein kinases identified a cDNA clone encoding a putative kinase with predicted serine/threonine phosphorylation specificity.
K W, Johnson, K A, Smith
openaire +2 more sources
Stress activated protein kinase pathway modulates homologous recombination in fission yeast.
PLoS ONE, 2012 Rad52 is a key player in homologous recombination (HR), a DNA repair pathway that is dedicated to double strand breaks repair and recovery of perturbed replication forks.
Angela Bellini +5 more
doaj +1 more source
Casein kinase 2 controls synapse organization and stability [PDF]
, 2013 Synapse remodeling is a local and dynamic process, requiring constant modifications of the neuronal network. Post-translational modifications, such as reversible phosphorylation by kinases and phosphatases, play a crucial role in synapse development and ...
Bulat, Victoria
core +1 more source
PLoS ONE, 2017 CIL-102 (1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a well-known, major active agent of the alkaloid derivative of Camptotheca acuminata with valuable biological properties, including anti-tumorigenic activity. In this study, we investigated
Wen-Shih Huang +9 more
doaj +1 more source
PLoS ONE, 2013 The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes trypanosomiasis in humans and animals. Both the life cycle and cell cycle of the parasite are complex. Trypanosomes have eleven cdc2-related kinases (CRKs) and ten cyclins,
Séverine Monnerat +9 more
doaj +1 more source
Targeting the Cdc2‐like kinase 2 for overcoming platinum resistance in ovarian cancer
MedCommPlatinum resistance represents a major barrier to the survival of patients with ovarian cancer (OC). Cdc2‐like kinase 2 (CLK2) is a major protein kinase associated with oncogenic phenotype and development in some solid tumors. However, the exact role and
Yinan Jiang +17 more
doaj +1 more source
Pectenotoxin-2 from Marine Sponges: A Potential Anti-Cancer Agent—A Review
Marine Drugs, 2011 Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of ...
Wun-Jae Kim +2 more
doaj +1 more source
BMC Gastroenterology, 2009 Background 3,3'-Diindolylmethane (DIM), an indole derivative produced in the stomach after the consumption of broccoli and other cruciferous vegetables, has been demonstrated to exert anti-cancer effects in both in vivo and in vitro models.
Choi Hyun, Lim Do, Park Jung
doaj +1 more source
Phosphorylation of amyloid-ß at the serine 26 residue by human cdc2 kinase
, 2001 The amyloid-β (Aβ) peptide has been implicated in the pathology of Alzheimer's disease (AD). Using an antisense peptide approach a novel interaction between Aβ and the human cdc2 kinase was identified.
Milton, N.G.N.
core
Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]
, 2000 The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David +16 more
core +1 more source