Results 101 to 110 of about 4,659,967 (205)

Beacon interacts with CDC2/CDC28-like protein kinase 4

, 2002
Beacon interacts with CDC2/CDC28-like protein kinase
Gregory Collier (13049697), L Kerr-Bayles (13281264), Ken Walder (13099344), Lakshmi Kantham (13049745), T Sunderland (7799669)   +4 more
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Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus

, 1996
A synthetic peptide corresponding in sequence to residues 6-20 of p34(cdc2), cdc2(6-20), and a substitution analogue, cdc2(6-20)F15K19, which contains Thr-14 as the only phosphorylation target were used as substrates to identify a novel protein kinase in
Wang, Jerry H., Matsuura, Isao
core   +1 more source

Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells

BMC Gastroenterology, 2009
Background 3,3'-Diindolylmethane (DIM), an indole derivative produced in the stomach after the consumption of broccoli and other cruciferous vegetables, has been demonstrated to exert anti-cancer effects in both in vivo and in vitro models.
Choi Hyun, Lim Do, Park Jung
doaj   +1 more source

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum

, 1995
A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family.
Coyle, J., Arnot, D., Carlton, J., Sultan, A., Doerig, C. M., Doerig, C., Horrocks, P., Carter, R., Paul Horrocks, Caroline Doerig, Ali Sultan, Christian Doerig, Joseph Coyle, Richard Carter, David Arnot, Jane Carlton   +15 more
core   +1 more source

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Mayer, Bettina A., Nina Berberich, Stefan Zahler, Sass, Gabriele, Fritz Krombach, Vollmar, Angelika M., Tiegs, Gisa, Krombach, Fritz, Fürst, Robert, Robert Fürst, Totzke, Frank, Angelika M. Vollmar, Jos Joore, Gisa Tiegs, Berberich, Nina, Alexander G. Khandoga, Bettina A. Mayer, Joore, Jos, Ulrike K. Schmerwitz, Gabriele Sass, Zahler, Stefan, Frank Totzke, Schmerwitz, Ulrike K., Khandoga, Alexander G.   +23 more
core   +1 more source

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
doaj   +1 more source

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

, 2002
The availability of a sister chromatid, and thus the cell cycle phase in which DNA double-strand breaks (DSBs) occur, influences the choice between homologous recombination (HR) or nonhomologous end joining (NHEJ).
Jo Murray (4460464), Thomas Caspari (155113), Antony Carr (4561024)   +2 more
core   +1 more source

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

, 1989
p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and
Harlow, E., Franza, B. R. Jr, Draetta, G., Draetta, G., Beach, D., Giordano, A., Harlow, E., Whyte, P., Whyte, P., Franza, B. R., Giordano, A., Beach, D.   +11 more
core   +1 more source

Neuronal Cdc2-like kinase: From cell cycle to neuronal function

, 1996
Neuronal Cdc2-like kinase, Nclk, is a heterodimer of cyclin-dependent protein kinase 5 (Cdk5) and a 25-kDa essential regulatory subunit that is derived from a 35-kDa brain- and neuron-specific protein.
Wang, Jerry H., Matsuura, Isao, Lee, Ki Young, Qi, Zhong, Tang, Damu   +4 more
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A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2 [PDF]

, 1992
The Eg1 gene in Xenopus laevis is related in sequence to the cdc2+ gene. We show here that the Eg1 gene product (cdk2) possesses histone H1 protein kinase activity and binds to PSTAIR antibodies as well as to Sepharose beads linked to the 13-kDa product ...
Gautier, Jean, Gabrielli, Brian G., Philippe, Michel, Roy, Linda M., Maller, James L.   +4 more
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