Results 111 to 120 of about 4,659,967 (205)

Up-regulation of cdc2 protein during paclitaxel-induced apoptosis

, 2000
International audienceMicrotubule damages induced by paclitaxel inhibit proteasome-dependent degradation of cyclin B, resulting in a sustained activation of cyclin B/cdc2 kinase and a cell cycle arrest in mitosis.
Truchet, Isabelle, Valette, Annie, Brichese, Laetitia, Chadebech, Philippe, Meier R, Giovanoli O, Nooijen, Peet T.G.A., Humar B, Ten Hagen, Timo L.M., Eggermont, Alexander M.M., Parent, Marie-Élise, Attenhofer M, Müller H, Bendik I, Van Tiel, Sandra T.; id_orcid, Siemiatycki, Jack, Seynhaeve, Ann L.B., Dobbie Z, Van Der Veen, Alexander H., Wolf A, Dumas, Simone, Brisson, Jacques   +21 more
core   +1 more source

cdc2 Cyclin-Dependent Kinase Binds and Phosphorylates Herpes Simplex Virus 1 U _L 42 DNA Synthesis Processivity Factor

, 2001
Earlier studies have shown that cdc2 kinase is activated during herpes simplex virus 1 infection and that its activity is enhanced late in infection even though the levels of cyclin A and B are decreased below levels of detection. Furthermore, activation
Bernard Roizman, Sunil J. Advani, Ralph R. Weichselbaum   +2 more
core   +1 more source

The Addition of Mitogen-Activated Protein (MAP) Kinase and p34(cdc2) Kinase Substrate Peptides Inhibits the Flagellar Motility of Demembranated Fowl Spermatozoa [PDF]

The motility of demembranated fowl spermatozoa was vigorous at 30°C, but decreased markedly following the addition of mitogen-activated protein （MAP） kinase or p34（cdc2） kinase substrate peptide.
Higashio, Mari, 5320, Ashizawa, Koji, 2104, アシザワ, コウジ, Tsuzuki, Yasuhiro, 續木, 靖浩, ツヅキ, ヤスヒロ, 00236928, 932, Hashimoto, Kei, 芦沢, 幸二, 5319   +12 more
core   +2 more sources

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

Molecular Oncology
In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency.
Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer   +8 more
doaj   +1 more source

Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit [PDF]

, 1989
p34 kinase, the product of the CDC2 gene, is a cell-cycle regulated protein kinase that is most active during mitosis. In HeLa cells, p34 kinase has previously been shown to exist in both a low- and a high-molecular-mass form, the latter of which is only
Draetta, G., Brizuela, L., Beach, D.
core  

cdc2 Protein Kinase: Interactions with Cyclins and sucl

Cold Spring Harbor Symposia on Quantitative Biology, 1991
P. Brambilla, B. Ducommun, G. Draetta
openaire   +1 more source

Pde1b controls cyclic nucleotide signaling in cDC1 and macrophages to regulate immune responses. [PDF]

EMBO Rep
Rekowsky LLO, da Silva RLL, Seenarine JA, Resende AS, Macchietto M, de Moura TR, Elizondo DM, Lipscomb MW.   +7 more
europepmc   +1 more source

Benzyladenine promotes early activation of p34(cdc2)-like kinase(s) during maize germination

, 1999
The cell cycle is regulated, at least partially, by protein phosphorylation, activity that is carried out by a series of calcium-independent protein kinases among which the p34(cdc2) kinase plays a preponderant role.
Vazquez-Ramos, JM, Jiménez-García, LF, Herrera-Teigeiro, I   +2 more
core  

Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression. [PDF]

J Dev Biol
Pfeiffer S, Fernando LM, Allen AK, Jaramillo-Lambert A.   +3 more
europepmc   +1 more source

An Ancestral Mechanism of Calmodulin Binding to Cds1 Kinase Inhibits Catalytic Activity. [PDF]

IUBMB Life
Manovella SA, Wang T, Young SN, Dite TA, Vaibhav V, Binos S, Dagley LF, Nguyen ATN, Means AR, Petersen J, Scott JW, Murphy JM, Horne CR.   +12 more
europepmc   +1 more source