Results 111 to 120 of about 3,589,787 (212)

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization

, 1989
The products of the cdc13+ and cdc2+ genes form a stable complex that displays protein kinase activity in vitro. p63cdc13 is a substrate of p34cdc2, the catalytic subunit of the kinase.
Beach, D. H., Booher, R. N., Alfa, C. E., Hyams, J. S.   +3 more
core   +1 more source

Investigation of CDC2-independent mitotic protein kinases

, 1997
Mitosis is a highly coordinated event which ensures the equal segregation of the cytoplasmic and genetic material into two daughter cells. A key regulatory process in ensuring the temporal fidelity of mitosis involves reversible protein phosphorylation
Gowdy, Patrick Michael
core   +1 more source

Up-regulation of cdc2 protein during paclitaxel-induced apoptosis

, 2000
International audienceMicrotubule damages induced by paclitaxel inhibit proteasome-dependent degradation of cyclin B, resulting in a sustained activation of cyclin B/cdc2 kinase and a cell cycle arrest in mitosis.
Truchet, Isabelle, Valette, Annie, Brichese, Laetitia, Chadebech, Philippe   +3 more
core   +1 more source

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

, 2002
The availability of a sister chromatid, and thus the cell cycle phase in which DNA double-strand breaks (DSBs) occur, influences the choice between homologous recombination (HR) or nonhomologous end joining (NHEJ).
Jo Murray (4460464), Thomas Caspari (155113), Antony Carr (4561024)   +2 more
core   +1 more source

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

Molecular Oncology
In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency.
Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer   +8 more
doaj   +1 more source

Beacon interacts with CDC2/CDC28-like protein kinase 4

, 2002
Beacon interacts with CDC2/CDC28-like protein kinase
Gregory Collier (13049697), L Kerr-Bayles (13281264), Ken Walder (13099344), Lakshmi Kantham (13049745), T Sunderland (7799669)   +4 more
core  

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]

, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core  

Functional studies of serine/threonine protein kinase signalling in Mycobacterium tuberculosis. [PDF]

, 2006
Fork-head associated (FHA) domains function in the assembly of signalling complexes through specific interactions with phospho-threonine motifs. FHA domains are found in eukaryotes, and intriguingly in a subset of bacterial species including Mycobacteria
Patel, D.P.
core